A yeast-based system to study SARS-CoV-2 M(pro) structure and to identify nirmatrelvir resistant mutations

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The SARS-CoV-2 main protease (M(pro)) is a major therapeutic target. The M(pro) inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As M(pro) inhibitor use increases, drug resistant mutations will likely emerge. We have established a non-patho...

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Detalles Bibliográficos
Autores principales: Ou, Jin, Lewandowski, Eric M., Hu, Yanmei, Lipinski, Austin A., Aljasser, Ali, Colon-Ascanio, Mariliz, Morgan, Ryan T., Jacobs, Lian M. C., Zhang, Xiujun, Bikowitz, Melissa J., Langlais, Paul R., Tan, Haozhou, Wang, Jun, Chen, Yu, Choy, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499260/
https://www.ncbi.nlm.nih.gov/pubmed/37651467
http://dx.doi.org/10.1371/journal.ppat.1011592
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