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Reduced visual context effects in global motion processing in depression

Research supports abnormal inhibitory visual motion processing in adults with remitted and current depression, but all studies to date have used paradigms with simple grating stimuli. Global motion processing, where multiple motion signals must be integrated, has not been explored in depression, nor...

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Autores principales: Murray, Grace E., Norton, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499266/
https://www.ncbi.nlm.nih.gov/pubmed/37703305
http://dx.doi.org/10.1371/journal.pone.0291513
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author Murray, Grace E.
Norton, Daniel J.
author_facet Murray, Grace E.
Norton, Daniel J.
author_sort Murray, Grace E.
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description Research supports abnormal inhibitory visual motion processing in adults with remitted and current depression, but all studies to date have used paradigms with simple grating stimuli. Global motion processing, where multiple motion signals must be integrated, has not been explored in depression, nor have inhibitory processes within that domain. Depressed participants (n = 46) and healthy controls (n = 28) completed a direction discrimination task featuring a random dot pattern stimulus. Various signal (rightward or leftward dots) to noise (dots with randomly assigned directions) ratios modulated task difficulty. Metrics of global center surround suppression and facilitation were calculated. Accuracy in the baseline condition (i.e., no surrounding annulus) was not significantly different between depressed and healthy participants. Global center surround suppression and facilitation were not significantly different between healthy and depressed participants overall. When limiting the sample to unmedicated individuals, depressed participants (n = 27) showed a reduced global center surround suppression effect compared to controls, and there was no difference in global center surround facilitation. While global motion processing is intact in depression, abnormal center surround suppression effects in depression do extend to global motion stimuli. These alterations may be mitigated by the psychotropic medications taken by some subjects in our depressed sample. Future studies should explore the mechanisms underlying these effects.
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spelling pubmed-104992662023-09-14 Reduced visual context effects in global motion processing in depression Murray, Grace E. Norton, Daniel J. PLoS One Research Article Research supports abnormal inhibitory visual motion processing in adults with remitted and current depression, but all studies to date have used paradigms with simple grating stimuli. Global motion processing, where multiple motion signals must be integrated, has not been explored in depression, nor have inhibitory processes within that domain. Depressed participants (n = 46) and healthy controls (n = 28) completed a direction discrimination task featuring a random dot pattern stimulus. Various signal (rightward or leftward dots) to noise (dots with randomly assigned directions) ratios modulated task difficulty. Metrics of global center surround suppression and facilitation were calculated. Accuracy in the baseline condition (i.e., no surrounding annulus) was not significantly different between depressed and healthy participants. Global center surround suppression and facilitation were not significantly different between healthy and depressed participants overall. When limiting the sample to unmedicated individuals, depressed participants (n = 27) showed a reduced global center surround suppression effect compared to controls, and there was no difference in global center surround facilitation. While global motion processing is intact in depression, abnormal center surround suppression effects in depression do extend to global motion stimuli. These alterations may be mitigated by the psychotropic medications taken by some subjects in our depressed sample. Future studies should explore the mechanisms underlying these effects. Public Library of Science 2023-09-13 /pmc/articles/PMC10499266/ /pubmed/37703305 http://dx.doi.org/10.1371/journal.pone.0291513 Text en © 2023 Murray, Norton https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Murray, Grace E.
Norton, Daniel J.
Reduced visual context effects in global motion processing in depression
title Reduced visual context effects in global motion processing in depression
title_full Reduced visual context effects in global motion processing in depression
title_fullStr Reduced visual context effects in global motion processing in depression
title_full_unstemmed Reduced visual context effects in global motion processing in depression
title_short Reduced visual context effects in global motion processing in depression
title_sort reduced visual context effects in global motion processing in depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499266/
https://www.ncbi.nlm.nih.gov/pubmed/37703305
http://dx.doi.org/10.1371/journal.pone.0291513
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