Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor. There are no approved treatments to treat NASH. Here, we first used single-nucleus RNA sequencing to characterize a mouse mo...

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Detalles Bibliográficos
Autores principales: Boslem, Ebru, Reibe, Saskia, Carlessi, Rodrigo, Smeuninx, Benoit, Tegegne, Surafel, Egan, Casey L., McLennan, Emma, Terry, Lauren V., Nobis, Max, Mu, Andre, Nowell, Cameron, Horadagoda, Neil, Mellett, Natalie A., Timpson, Paul, Jones, Matthew, Denisenko, Elena, Forrest, Alistair R. R., Tirnitz-Parker, Janina E. E., Meikle, Peter J., Rose-John, Stefan, Karin, Michael, Febbraio, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499313/
https://www.ncbi.nlm.nih.gov/pubmed/37703359
http://dx.doi.org/10.1126/sciadv.adh0831

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