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IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus

Norovirus is a leading cause of epidemic viral gastroenteritis, with no currently approved vaccines or antivirals. Murine norovirus (MNoV) is a well-characterized model of norovirus pathogenesis in vivo, and persistent strains exhibit lifelong intestinal infection. Interferon-λ (IFN-λ) is a potent a...

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Detalles Bibliográficos
Autores principales:	Ingle, Harshad, Makimaa, Heyde, Aggarwal, Somya, Deng, Hongju, Foster, Lynne, Li, Yuhao, Kennedy, Elizabeth A., Peterson, Stefan T., Wilen, Craig B., Lee, Sanghyun, Suthar, Mehul S., Baldridge, Megan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499323/ https://www.ncbi.nlm.nih.gov/pubmed/37703370 http://dx.doi.org/10.1126/sciadv.adi2562

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