Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x(C)(−)

Glutathione (GSH) is a critical component of the cellular redox system that combats oxidative stress. The glutamate-cystine antiporter, system x(C)(−), is a key player in GSH synthesis that allows for the uptake of cystine, the rate-limiting building block of GSH. It is unclear whether GSH or GSH-de...

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Detalles Bibliográficos
Autores principales: Aboushousha, Reem, van der Velden, Jos, Hamilton, Nicholas, Peng, Zhihua, MacPherson, Maximilian, Erickson, Cuixia, White, Sheryl, Wouters, Emiel F. M., Reynaert, Niki L., Seward, David J., Li, Jianing, Janssen-Heininger, Yvonne M. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499329/
https://www.ncbi.nlm.nih.gov/pubmed/37703360
http://dx.doi.org/10.1126/sciadv.adi5192

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