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3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle

Mechanosensory corpuscles detect transient touch and vibration in the skin of vertebrates, enabling precise sensation of the physical environment. The corpuscle contains a mechanoreceptor afferent surrounded by lamellar cells (LCs), but corpuscular ultrastructure and the role of LCs in touch detecti...

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Autores principales: Nikolaev, Yury A., Ziolkowski, Luke H., Pang, Song, Li, Wei-Ping, Feketa, Viktor V., Xu, C. Shan, Gracheva, Elena O., Bagriantsev, Sviatoslav N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499330/
https://www.ncbi.nlm.nih.gov/pubmed/37703368
http://dx.doi.org/10.1126/sciadv.adi4147
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author Nikolaev, Yury A.
Ziolkowski, Luke H.
Pang, Song
Li, Wei-Ping
Feketa, Viktor V.
Xu, C. Shan
Gracheva, Elena O.
Bagriantsev, Sviatoslav N.
author_facet Nikolaev, Yury A.
Ziolkowski, Luke H.
Pang, Song
Li, Wei-Ping
Feketa, Viktor V.
Xu, C. Shan
Gracheva, Elena O.
Bagriantsev, Sviatoslav N.
author_sort Nikolaev, Yury A.
collection PubMed
description Mechanosensory corpuscles detect transient touch and vibration in the skin of vertebrates, enabling precise sensation of the physical environment. The corpuscle contains a mechanoreceptor afferent surrounded by lamellar cells (LCs), but corpuscular ultrastructure and the role of LCs in touch detection are unknown. We report the three-dimensional architecture of the avian Meissner (Grandry) corpuscle acquired using enhanced focused ion beam scanning electron microscopy and machine learning-based segmentation. The corpuscle comprises a stack of LCs interdigitated with terminal endings from two afferents. Simultaneous electrophysiological recordings from both cell types revealed that mechanosensitive LCs use calcium influx to trigger action potentials in the afferent and thus serve as physiological touch sensors in the skin. The elaborate architecture and bicellular sensory mechanism in the corpuscles, which comprises the afferents and LCs, create the capacity for nuanced encoding of the submodalities of touch.
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spelling pubmed-104993302023-09-14 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle Nikolaev, Yury A. Ziolkowski, Luke H. Pang, Song Li, Wei-Ping Feketa, Viktor V. Xu, C. Shan Gracheva, Elena O. Bagriantsev, Sviatoslav N. Sci Adv Neuroscience Mechanosensory corpuscles detect transient touch and vibration in the skin of vertebrates, enabling precise sensation of the physical environment. The corpuscle contains a mechanoreceptor afferent surrounded by lamellar cells (LCs), but corpuscular ultrastructure and the role of LCs in touch detection are unknown. We report the three-dimensional architecture of the avian Meissner (Grandry) corpuscle acquired using enhanced focused ion beam scanning electron microscopy and machine learning-based segmentation. The corpuscle comprises a stack of LCs interdigitated with terminal endings from two afferents. Simultaneous electrophysiological recordings from both cell types revealed that mechanosensitive LCs use calcium influx to trigger action potentials in the afferent and thus serve as physiological touch sensors in the skin. The elaborate architecture and bicellular sensory mechanism in the corpuscles, which comprises the afferents and LCs, create the capacity for nuanced encoding of the submodalities of touch. American Association for the Advancement of Science 2023-09-13 /pmc/articles/PMC10499330/ /pubmed/37703368 http://dx.doi.org/10.1126/sciadv.adi4147 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Nikolaev, Yury A.
Ziolkowski, Luke H.
Pang, Song
Li, Wei-Ping
Feketa, Viktor V.
Xu, C. Shan
Gracheva, Elena O.
Bagriantsev, Sviatoslav N.
3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title_full 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title_fullStr 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title_full_unstemmed 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title_short 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
title_sort 3d architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499330/
https://www.ncbi.nlm.nih.gov/pubmed/37703368
http://dx.doi.org/10.1126/sciadv.adi4147
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