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Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis
BACKGROUND: A new classification for periodontitis has been adopted in clinical practice. However, there are still discussions regarding this new classification and difficulties in its adoption, both by professionals and researchers. Thus, this study aimed to evaluate which salivary biomarkers are p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499340/ https://www.ncbi.nlm.nih.gov/pubmed/37026605 http://dx.doi.org/10.4317/medoral.25876 |
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author | Gomes, Paulo Roberto Carneiro da Rocha, Maria Débora Rodrigues de Lira, John Arlley Sousa Pinho Coelho, Francisco Alex da Rocha Alves, Even Herlany Pereira Nascimento, Hélio Mateus Silva de Oliveira, Samara Marques Carmo, Rubens Renato de Sousa Araújo, Havila Torres da Silva, Felipe Rodolfo Pereira Vasconcelos, Daniel Fernando Pereira |
author_facet | Gomes, Paulo Roberto Carneiro da Rocha, Maria Débora Rodrigues de Lira, John Arlley Sousa Pinho Coelho, Francisco Alex da Rocha Alves, Even Herlany Pereira Nascimento, Hélio Mateus Silva de Oliveira, Samara Marques Carmo, Rubens Renato de Sousa Araújo, Havila Torres da Silva, Felipe Rodolfo Pereira Vasconcelos, Daniel Fernando Pereira |
author_sort | Gomes, Paulo Roberto Carneiro |
collection | PubMed |
description | BACKGROUND: A new classification for periodontitis has been adopted in clinical practice. However, there are still discussions regarding this new classification and difficulties in its adoption, both by professionals and researchers. Thus, this study aimed to evaluate which salivary biomarkers are present in periodontitis, following the new classification of periodontal diseases through meta-analysis. MATERIAL AND METHODS: A literature search was carried out in the scientific databases: PubMed, Scielo and Google scholar to select studies. The selection of studies was followed by two authors upon reading of the title, abstract and full text. The necessary data were collected and statistical analyses were performed using the Review Manager statistical software version 5.4, with calculation of Mean Difference, heterogeneity (I²) and funnel plot with P < 0.05. RESULTS: After following the selection criteria, 9 articles were selected for comparison. The studies address the presence of biomarkers in the saliva of patients with periodontitis and their possible use in the monitoring and diagnosis of the disease. For the meta-analytic comparison, a sample size of 1,983 individuals was used. Statistical analyses showed that nitric oxide, IL-6, IL-1B and osteoprotegerin are substances that are significantly present in patients with periodontitis (P < 0.05). CONCLUSIONS: IL-6, nitric oxide, IL-1B, TNF-α and osteoprotegerin are among the most present biomarkers in patients with periodontitis, and may be used in the future as a monitoring of periodontal disease. The present study also revealed that there was no statistically significant difference in the concentration of these biomarkers for clinical distinction from periodontitis. Key words:Periodontal disease, diagnosis, spittle. |
format | Online Article Text |
id | pubmed-10499340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104993402023-09-14 Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis Gomes, Paulo Roberto Carneiro da Rocha, Maria Débora Rodrigues de Lira, John Arlley Sousa Pinho Coelho, Francisco Alex da Rocha Alves, Even Herlany Pereira Nascimento, Hélio Mateus Silva de Oliveira, Samara Marques Carmo, Rubens Renato de Sousa Araújo, Havila Torres da Silva, Felipe Rodolfo Pereira Vasconcelos, Daniel Fernando Pereira Med Oral Patol Oral Cir Bucal Review BACKGROUND: A new classification for periodontitis has been adopted in clinical practice. However, there are still discussions regarding this new classification and difficulties in its adoption, both by professionals and researchers. Thus, this study aimed to evaluate which salivary biomarkers are present in periodontitis, following the new classification of periodontal diseases through meta-analysis. MATERIAL AND METHODS: A literature search was carried out in the scientific databases: PubMed, Scielo and Google scholar to select studies. The selection of studies was followed by two authors upon reading of the title, abstract and full text. The necessary data were collected and statistical analyses were performed using the Review Manager statistical software version 5.4, with calculation of Mean Difference, heterogeneity (I²) and funnel plot with P < 0.05. RESULTS: After following the selection criteria, 9 articles were selected for comparison. The studies address the presence of biomarkers in the saliva of patients with periodontitis and their possible use in the monitoring and diagnosis of the disease. For the meta-analytic comparison, a sample size of 1,983 individuals was used. Statistical analyses showed that nitric oxide, IL-6, IL-1B and osteoprotegerin are substances that are significantly present in patients with periodontitis (P < 0.05). CONCLUSIONS: IL-6, nitric oxide, IL-1B, TNF-α and osteoprotegerin are among the most present biomarkers in patients with periodontitis, and may be used in the future as a monitoring of periodontal disease. The present study also revealed that there was no statistically significant difference in the concentration of these biomarkers for clinical distinction from periodontitis. Key words:Periodontal disease, diagnosis, spittle. Medicina Oral S.L. 2023-09 2023-04-07 /pmc/articles/PMC10499340/ /pubmed/37026605 http://dx.doi.org/10.4317/medoral.25876 Text en Copyright: © 2023 Medicina Oral S.L. https://creativecommons.org/licenses/by/2.5/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gomes, Paulo Roberto Carneiro da Rocha, Maria Débora Rodrigues de Lira, John Arlley Sousa Pinho Coelho, Francisco Alex da Rocha Alves, Even Herlany Pereira Nascimento, Hélio Mateus Silva de Oliveira, Samara Marques Carmo, Rubens Renato de Sousa Araújo, Havila Torres da Silva, Felipe Rodolfo Pereira Vasconcelos, Daniel Fernando Pereira Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title | Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title_full | Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title_fullStr | Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title_full_unstemmed | Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title_short | Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
title_sort | salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499340/ https://www.ncbi.nlm.nih.gov/pubmed/37026605 http://dx.doi.org/10.4317/medoral.25876 |
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