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Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases

As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary disorders and upper respiratory tract infections. Wh...

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Autores principales: Casado, Enrique, Costa, Ester, Mezquita-Raya, Pedro, Andújar-Espinosa, Rubén, Neyro, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioExcel Publishing Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499368/
https://www.ncbi.nlm.nih.gov/pubmed/37711731
http://dx.doi.org/10.7573/dic.2023-5-4
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author Casado, Enrique
Costa, Ester
Mezquita-Raya, Pedro
Andújar-Espinosa, Rubén
Neyro, José Luis
author_facet Casado, Enrique
Costa, Ester
Mezquita-Raya, Pedro
Andújar-Espinosa, Rubén
Neyro, José Luis
author_sort Casado, Enrique
collection PubMed
description As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary disorders and upper respiratory tract infections. While optimal target concentrations of serum 25-hydroxyvitamin D (25(OH)D) for health maintenance or therapeutic purposes are still the subject of debate, there is reasonable agreement that serum 25(OH)D levels <50 nmol/L (20 ng/mL) constitute vitamin D deficiency and that severe deficiency states (serum 25(OH)D levels <25–30 nmol/L ≈ 10–12 ng/mL) should be avoided. Main strategies to maintain or improve vitamin D status are food supplementation and therapeutic use of medicinal forms of vitamin D. In this review, we examine evidence that implicates vitamin D deficiency in diverse conditions in the clinical settings of endocrinology, rheumatology, pneumology and reproductive health. Cholecalciferol (vitamin D(3)) is the most frequently used vitamin D supplement worldwide, though calcifediol (25-hydroxyvitamin D(3)) has recently become more widely available. Calcifediol is one step closer than cholecalciferol in the metabolic pathway to biologically active vitamin D. Pharmacokinetic differences between these vitamin D metabolites confer putative advantages for calcifediol in certain clinical situations. The clinical use of calcifediol is explored more closely through case studies, which illustrate its adjunctive role in the treatment of several vitamin D deficiency-related skeletal and extraskeletal diseases.
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spelling pubmed-104993682023-09-14 Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases Casado, Enrique Costa, Ester Mezquita-Raya, Pedro Andújar-Espinosa, Rubén Neyro, José Luis Drugs Context Review As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary disorders and upper respiratory tract infections. While optimal target concentrations of serum 25-hydroxyvitamin D (25(OH)D) for health maintenance or therapeutic purposes are still the subject of debate, there is reasonable agreement that serum 25(OH)D levels <50 nmol/L (20 ng/mL) constitute vitamin D deficiency and that severe deficiency states (serum 25(OH)D levels <25–30 nmol/L ≈ 10–12 ng/mL) should be avoided. Main strategies to maintain or improve vitamin D status are food supplementation and therapeutic use of medicinal forms of vitamin D. In this review, we examine evidence that implicates vitamin D deficiency in diverse conditions in the clinical settings of endocrinology, rheumatology, pneumology and reproductive health. Cholecalciferol (vitamin D(3)) is the most frequently used vitamin D supplement worldwide, though calcifediol (25-hydroxyvitamin D(3)) has recently become more widely available. Calcifediol is one step closer than cholecalciferol in the metabolic pathway to biologically active vitamin D. Pharmacokinetic differences between these vitamin D metabolites confer putative advantages for calcifediol in certain clinical situations. The clinical use of calcifediol is explored more closely through case studies, which illustrate its adjunctive role in the treatment of several vitamin D deficiency-related skeletal and extraskeletal diseases. BioExcel Publishing Ltd 2023-09-06 /pmc/articles/PMC10499368/ /pubmed/37711731 http://dx.doi.org/10.7573/dic.2023-5-4 Text en Copyright © 2023 Casado E, Costa E, Mezquita-Raya P, Andújar-Espinosa R, Neyro JL https://creativecommons.org/licenses/by-nc-nd/4.0/Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0, which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.
spellingShingle Review
Casado, Enrique
Costa, Ester
Mezquita-Raya, Pedro
Andújar-Espinosa, Rubén
Neyro, José Luis
Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title_full Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title_fullStr Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title_full_unstemmed Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title_short Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
title_sort calcifediol in the management of vitamin d deficiency-related skeletal and extraskeletal diseases: overview and clinical cases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499368/
https://www.ncbi.nlm.nih.gov/pubmed/37711731
http://dx.doi.org/10.7573/dic.2023-5-4
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