LAMP1 targeting of the large T antigen of Merkel cell polyomavirus results in potent CD4 T cell responses and tumor inhibition

INTRODUCTION: Most cases of Merkel cell carcinoma (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV integrates into the host genome, resulting in expression of oncoproteins including a truncated form of the v...

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Autores principales: Buchta Rosean, Claire, Leyder, Erica C., Hamilton, Jeneice, Carter, Joseph J., Galloway, Denise A., Koelle, David M., Nghiem, Paul, Heiland, Teri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499392/
https://www.ncbi.nlm.nih.gov/pubmed/37711623
http://dx.doi.org/10.3389/fimmu.2023.1253568

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