Cargando…

First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers

Inappropriate and chronic activation of the cytosolic NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome, a key component of innate immunity, likely underlies several inflammatory diseases, including coronary artery disease. This first‐in‐human phase I trial evaluated safety, pharmacokin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Fei, Kunder, Rebecca, Chu, Tom, Hains, Avis, Nguyen, Allen, McBride, Jacqueline M., Zhong, Yu, Santagostino, Sara, Wilson, Maria, Trenchak, Abigail, Chen, Liuxi, Ly, Justin, Moein, Anita, Lewin‐Koh, Nicholas, Raghavan, Vibha, Osaghae, Uyi, Wynne, Chris, Owen, Ryan, Place, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499406/ https://www.ncbi.nlm.nih.gov/pubmed/37350225 http://dx.doi.org/10.1111/cts.13576

Ejemplares similares

Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC‐0214 in healthy volunteers
por: Zhu, Rui, et al.
Publicado: (2022)

Translational and pharmacokinetic‐pharmacodynamic application for the clinical development of GDC‐0334, a novel TRPA1 inhibitor
por: Chan, Phyllis, et al.
Publicado: (2021)

2394. Comparative Analysis of Behavior Change and Vaccine Uptake Beliefs
por: Walsh, Tyler, et al.
Publicado: (2023)

PB2394: PTPRJ AS A ROBUST DIFFERENTIATING MARKER IN MANTLE CELL LYMPHOMA
por: Valentin Hansen, Simone, et al.
Publicado: (2023)

GDC respond to crisis
Publicado: (2020)

Mentoring, performance and the GDC
por: Saw, Mabel, et al.
Publicado: (2021)

2394. A Longitudinal Study of the Effect of Renal Failure on Readmission Rates of Patients with Clostridioides difficile
por: Destache, Christopher J, et al.
Publicado: (2019)

GDC announces new chair
Publicado: (2021)

A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
por: Katz, Jonathan S., et al.
Publicado: (2022)

2394. Different Clostridioides difficile Ribotypes Among Patients With Colonization, Initial Clinical Disease, and Recurrent Clinical Disease
por: Khoury, Kevin, et al.
Publicado: (2018)

2394 Sodium-glucose transporter 2 is a novel diagnostic and therapeutic target for early-stage lung adenocarcinoma
por: Scafoglio, Claudio, et al.
Publicado: (2018)

GDC 2: Compression of large collections of genomes
por: Deorowicz, Sebastian, et al.
Publicado: (2015)

GDC publishes 2019 fitness to practise statistics
Publicado: (2020)

GDC statement on complaints during the pandemic welcomed
Publicado: (2022)

GDC calls for DCPs to check CPD records
Publicado: (2022)

GDC calls for DCPs to check CPD records
Publicado: (2022)

GDC and CQC issue statement on life-support training
Publicado: (2020)

Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
por: Li, Junfeng, et al.
Publicado: (2015)

GDC highlights importance of clear public safety COVID information
Publicado: (2020)

A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers
por: Jones, Nicholas S., et al.
Publicado: (2023)

The Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Japanese Volunteers
por: Umemura, Kazuo, et al.
Publicado: (2016)

GDC-0941 activates integrin linked kinase (ILK) expression to cause resistance to GDC-0941 in breast cancer by the tumor necrosis factor (TNF)-α signaling pathway
por: Chen, Haifeng, et al.
Publicado: (2022)

eDAVE – Extension of GDC data analysis, visualization, and exploration tools
por: Bińkowski, Jan, et al.
Publicado: (2023)

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers
por: Gillen, Michael, et al.
Publicado: (2016)

Population Pharmacokinetics and Pharmacodynamics of Benralizumab in Healthy Volunteers and Patients With Asthma
por: Wang, B, et al.
Publicado: (2017)

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers
por: Peterschmitt, M. Judith, et al.
Publicado: (2020)

Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress
por: Hains, Avis Brennan, et al.
Publicado: (2015)

Annealing of Gadolinium-Doped Ceria (GDC) Films Produced by the Aerosol Deposition Method
por: Exner, Jörg, et al.
Publicado: (2018)

GDC-0349 inhibits non-small cell lung cancer cell growth
por: Yang, Han, et al.
Publicado: (2020)

Evaluation of the pharmacokinetics and pharmacodynamics of ticagrelor co-administered with aspirin in healthy volunteers
por: Teng, Renli, et al.
Publicado: (2013)

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers
por: Yoon, Deok Y., et al.
Publicado: (2021)

Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers
por: Wang, Shining, et al.
Publicado: (2022)

Gastric duplication cyst (gdc) associated with ectopic pancreas: Case report and review of the literature
por: Passos, I.D., et al.
Publicado: (2017)

New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx
por: Mounir, Mohamed, et al.
Publicado: (2019)

Calls for GDC leniency as third of dentists say fear of investigation is affecting mental wellbeing
Publicado: (2020)

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
por: Shekhar, Tanmay M., et al.
Publicado: (2019)

Pharmacokinetic and pharmacodynamic effects of comedication of clopidogrel and dabigatran etexilate in healthy male volunteers
por: Härtter, Sebastian, et al.
Publicado: (2012)

Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers
por: Nagelschmitz, J, et al.
Publicado: (2014)

Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers
por: Lee, Jieon, et al.
Publicado: (2014)

Pharmacokinetics and pharmacodynamics of levofloxacin injection in healthy Chinese volunteers and dosing regimen optimization
por: Cao, G, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_cekcrqvrphir2qitr3pnumv0nf