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Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and guide analyt...

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Detalles Bibliográficos
Autores principales:	Shannon, Morgan L., Muhammad, Ayesha, James, Nathan T., Williams, Michael L., Breeyear, Joseph, Edwards, Todd, Mosley, Jonathan D., Choi, Leena, Kannankeril, Prince, Van Driest, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499425/ https://www.ncbi.nlm.nih.gov/pubmed/37353859 http://dx.doi.org/10.1111/cts.13574

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