Cargando…
Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis
Aim: Serum levels of cholesterol absorption and synthesis markers are known to be associated with cardiovascular risk. Familial hypercholesterolemia (FH) is a well-known inherited disorder presenting elevated low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels and premature...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499464/ https://www.ncbi.nlm.nih.gov/pubmed/36624055 http://dx.doi.org/10.5551/jat.63899 |
_version_ | 1785105715262652416 |
---|---|
author | Matsuki, Kota Harada-Shiba, Mariko Hori, Mika Ogura, Masatsune Akiyama, Yusuke Fujii, Hisako Ishibashi, Yutaka Ishida, Tatsuro Ishigaki, Yasushi Kabata, Daijiro Kihara, Yasuki Kotani, Kazuhiko Kurisu, Satoshi Masuda, Daisaku Matoba, Tetsuya Matsumura, Takeshi Mori, Kenta Nakagami, Tomoko Nakazato, Masamitsu Taniuchi, Satsuki Ueno, Hiroaki Yamashita, Shizuya Yoshida, Hiroshi Yoshida, Hisako Shoji, Tetsuo |
author_facet | Matsuki, Kota Harada-Shiba, Mariko Hori, Mika Ogura, Masatsune Akiyama, Yusuke Fujii, Hisako Ishibashi, Yutaka Ishida, Tatsuro Ishigaki, Yasushi Kabata, Daijiro Kihara, Yasuki Kotani, Kazuhiko Kurisu, Satoshi Masuda, Daisaku Matoba, Tetsuya Matsumura, Takeshi Mori, Kenta Nakagami, Tomoko Nakazato, Masamitsu Taniuchi, Satsuki Ueno, Hiroaki Yamashita, Shizuya Yoshida, Hiroshi Yoshida, Hisako Shoji, Tetsuo |
author_sort | Matsuki, Kota |
collection | PubMed |
description | Aim: Serum levels of cholesterol absorption and synthesis markers are known to be associated with cardiovascular risk. Familial hypercholesterolemia (FH) is a well-known inherited disorder presenting elevated low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels and premature coronary disease. In this study, we aim to examine the differences in terms of serum markers of cholesterol metabolism between FH and non-FH individuals and to examine their associations with serum lipid levels. Methods: In this study, we utilized data on serum markers of cholesterol metabolism, namely, lathosterol (Latho, synthesis marker), campesterol (Campe, absorption marker), and sitosterol (Sito, absorption marker) measured by gas chromatography of the CACHE consortium, which comprised of 13 research groups in Japan. Clinical data were compiled using REDCap system. Among the 2944 individuals in the CACHE population, we selected individuals without lipid-lowering medications and hemodialysis patients for this CACHE study FH analysis. Multivariable adjustment was performed to assess the associations. Results: In this study, we analyzed data from 51 FH patients and 1924 non-FH individuals. After adjustment for possible confounders, the FH group was shown to have significantly higher Campe and Sito concentrations and insignificantly higher Latho concentrations than the non-FH group. These marker concentrations showed nonlinear associations with TC in the FH group. Campe/Latho and Sito/Latho ratios were significantly higher in the FH group than in the non-FH group. Conclusion: FH group had significantly elevated serum Campe and Sito concentrations and insignificantly elevated Latho concentrations; thus, intestinal cholesterol absorption relative to hepatic cholesterol synthesis was suggested to be elevated in patients with FH. Serum Latho, Campe, and Sito concentrations showed nonlinear associations with TC in the FH group. |
format | Online Article Text |
id | pubmed-10499464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-104994642023-09-14 Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis Matsuki, Kota Harada-Shiba, Mariko Hori, Mika Ogura, Masatsune Akiyama, Yusuke Fujii, Hisako Ishibashi, Yutaka Ishida, Tatsuro Ishigaki, Yasushi Kabata, Daijiro Kihara, Yasuki Kotani, Kazuhiko Kurisu, Satoshi Masuda, Daisaku Matoba, Tetsuya Matsumura, Takeshi Mori, Kenta Nakagami, Tomoko Nakazato, Masamitsu Taniuchi, Satsuki Ueno, Hiroaki Yamashita, Shizuya Yoshida, Hiroshi Yoshida, Hisako Shoji, Tetsuo J Atheroscler Thromb Original Article Aim: Serum levels of cholesterol absorption and synthesis markers are known to be associated with cardiovascular risk. Familial hypercholesterolemia (FH) is a well-known inherited disorder presenting elevated low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels and premature coronary disease. In this study, we aim to examine the differences in terms of serum markers of cholesterol metabolism between FH and non-FH individuals and to examine their associations with serum lipid levels. Methods: In this study, we utilized data on serum markers of cholesterol metabolism, namely, lathosterol (Latho, synthesis marker), campesterol (Campe, absorption marker), and sitosterol (Sito, absorption marker) measured by gas chromatography of the CACHE consortium, which comprised of 13 research groups in Japan. Clinical data were compiled using REDCap system. Among the 2944 individuals in the CACHE population, we selected individuals without lipid-lowering medications and hemodialysis patients for this CACHE study FH analysis. Multivariable adjustment was performed to assess the associations. Results: In this study, we analyzed data from 51 FH patients and 1924 non-FH individuals. After adjustment for possible confounders, the FH group was shown to have significantly higher Campe and Sito concentrations and insignificantly higher Latho concentrations than the non-FH group. These marker concentrations showed nonlinear associations with TC in the FH group. Campe/Latho and Sito/Latho ratios were significantly higher in the FH group than in the non-FH group. Conclusion: FH group had significantly elevated serum Campe and Sito concentrations and insignificantly elevated Latho concentrations; thus, intestinal cholesterol absorption relative to hepatic cholesterol synthesis was suggested to be elevated in patients with FH. Serum Latho, Campe, and Sito concentrations showed nonlinear associations with TC in the FH group. Japan Atherosclerosis Society 2023-09-01 2023-01-07 /pmc/articles/PMC10499464/ /pubmed/36624055 http://dx.doi.org/10.5551/jat.63899 Text en 2023 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Original Article Matsuki, Kota Harada-Shiba, Mariko Hori, Mika Ogura, Masatsune Akiyama, Yusuke Fujii, Hisako Ishibashi, Yutaka Ishida, Tatsuro Ishigaki, Yasushi Kabata, Daijiro Kihara, Yasuki Kotani, Kazuhiko Kurisu, Satoshi Masuda, Daisaku Matoba, Tetsuya Matsumura, Takeshi Mori, Kenta Nakagami, Tomoko Nakazato, Masamitsu Taniuchi, Satsuki Ueno, Hiroaki Yamashita, Shizuya Yoshida, Hiroshi Yoshida, Hisako Shoji, Tetsuo Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title | Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title_full | Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title_fullStr | Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title_full_unstemmed | Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title_short | Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis |
title_sort | association between familial hypercholesterolemia and serum levels of cholesterol synthesis and absorption markers: the cache study fh analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499464/ https://www.ncbi.nlm.nih.gov/pubmed/36624055 http://dx.doi.org/10.5551/jat.63899 |
work_keys_str_mv | AT matsukikota associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT haradashibamariko associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT horimika associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT oguramasatsune associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT akiyamayusuke associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT fujiihisako associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT ishibashiyutaka associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT ishidatatsuro associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT ishigakiyasushi associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT kabatadaijiro associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT kiharayasuki associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT kotanikazuhiko associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT kurisusatoshi associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT masudadaisaku associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT matobatetsuya associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT matsumuratakeshi associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT morikenta associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT nakagamitomoko associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT nakazatomasamitsu associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT taniuchisatsuki associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT uenohiroaki associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT yamashitashizuya associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT yoshidahiroshi associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT yoshidahisako associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis AT shojitetsuo associationbetweenfamilialhypercholesterolemiaandserumlevelsofcholesterolsynthesisandabsorptionmarkersthecachestudyfhanalysis |