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Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study

BACKGROUND: Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss through gastrin secretion. METHODS: Forty male rats were...

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Autores principales: Saki, Forough, Shams, Mesbah, Dastghaib, Sanaz, Koohpeyma, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499535/
https://www.ncbi.nlm.nih.gov/pubmed/37711876
http://dx.doi.org/10.1155/2023/2594664
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author Saki, Forough
Shams, Mesbah
Dastghaib, Sanaz
Koohpeyma, Farhad
author_facet Saki, Forough
Shams, Mesbah
Dastghaib, Sanaz
Koohpeyma, Farhad
author_sort Saki, Forough
collection PubMed
description BACKGROUND: Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss through gastrin secretion. METHODS: Forty male rats were divided into control, octreotide (Oct), pantoprazole (Pan), and pantoprazole plus octreotide (Pan+Oct) groups. Serum calcium, phosphorous, alkaline phosphatase, parathyroid hormone, and gastrin were measured before and three months after the treatment, and bone densitometry was examined. The rats' femoral bones were examined stereologically at the end of the investigation. RESULTS: The Pan group had considerably greater levels of serum alkaline phosphatase, parathyroid hormone (PTH), and gastrin, but this was prevented in the presence of Oct, a gastrin secretion inhibitor. All parameters of femoral bone densitometry in the Pan group were significantly lower than the control after treatment which was considerably inhibited in the presence of Oct. Furthermore, when compared to the control and Oct groups, the rats in the Pan group had a lower trabecular volume, femur bone weight, and volume, as well lower number of osteocytes. The amount of osteoclasts, on the other hand, was much higher in the Pan group than in the other groups. CONCLUSION: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition.
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spelling pubmed-104995352023-09-14 Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study Saki, Forough Shams, Mesbah Dastghaib, Sanaz Koohpeyma, Farhad Biomed Res Int Research Article BACKGROUND: Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss through gastrin secretion. METHODS: Forty male rats were divided into control, octreotide (Oct), pantoprazole (Pan), and pantoprazole plus octreotide (Pan+Oct) groups. Serum calcium, phosphorous, alkaline phosphatase, parathyroid hormone, and gastrin were measured before and three months after the treatment, and bone densitometry was examined. The rats' femoral bones were examined stereologically at the end of the investigation. RESULTS: The Pan group had considerably greater levels of serum alkaline phosphatase, parathyroid hormone (PTH), and gastrin, but this was prevented in the presence of Oct, a gastrin secretion inhibitor. All parameters of femoral bone densitometry in the Pan group were significantly lower than the control after treatment which was considerably inhibited in the presence of Oct. Furthermore, when compared to the control and Oct groups, the rats in the Pan group had a lower trabecular volume, femur bone weight, and volume, as well lower number of osteocytes. The amount of osteoclasts, on the other hand, was much higher in the Pan group than in the other groups. CONCLUSION: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition. Hindawi 2023-09-06 /pmc/articles/PMC10499535/ /pubmed/37711876 http://dx.doi.org/10.1155/2023/2594664 Text en Copyright © 2023 Forough Saki et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Saki, Forough
Shams, Mesbah
Dastghaib, Sanaz
Koohpeyma, Farhad
Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title_full Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title_fullStr Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title_full_unstemmed Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title_short Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
title_sort pantoprazole-induced bone loss through gastrin secretion: a stereological study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499535/
https://www.ncbi.nlm.nih.gov/pubmed/37711876
http://dx.doi.org/10.1155/2023/2594664
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