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Infections in patients with chronic lymphocytic leukemia
INTRODUCTION: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. METHOD AND RESULTS: However, once treat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499585/ https://www.ncbi.nlm.nih.gov/pubmed/37407362 http://dx.doi.org/10.1016/j.htct.2023.05.006 |
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author | Guarana, Mariana Nucci, Marcio |
author_facet | Guarana, Mariana Nucci, Marcio |
author_sort | Guarana, Mariana |
collection | PubMed |
description | INTRODUCTION: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. METHOD AND RESULTS: However, once treatment is initiated, the spectrum of pathogens causing infection broadens, depending on the treatment regimens. With disease progression, cumulative immunosuppression occurs as a consequence of multiple treatment lines and the risk of infection further increases. On the other hand, the use of targeted therapies in the treatment of CLL have brought new risks of infection, with an increased incidence of invasive fungal diseases, particularly aspergillosis, in patients receiving Bruton kinase inhibitors. CONCLUSION: In this article, we review the epidemiology of infection in patients with CLL, taking into account the treatment regimen, and briefly discuss the management of infection. |
format | Online Article Text |
id | pubmed-10499585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-104995852023-09-15 Infections in patients with chronic lymphocytic leukemia Guarana, Mariana Nucci, Marcio Hematol Transfus Cell Ther Review Article INTRODUCTION: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. METHOD AND RESULTS: However, once treatment is initiated, the spectrum of pathogens causing infection broadens, depending on the treatment regimens. With disease progression, cumulative immunosuppression occurs as a consequence of multiple treatment lines and the risk of infection further increases. On the other hand, the use of targeted therapies in the treatment of CLL have brought new risks of infection, with an increased incidence of invasive fungal diseases, particularly aspergillosis, in patients receiving Bruton kinase inhibitors. CONCLUSION: In this article, we review the epidemiology of infection in patients with CLL, taking into account the treatment regimen, and briefly discuss the management of infection. Sociedade Brasileira de Hematologia e Hemoterapia 2023 2023-07-01 /pmc/articles/PMC10499585/ /pubmed/37407362 http://dx.doi.org/10.1016/j.htct.2023.05.006 Text en © 2023 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Guarana, Mariana Nucci, Marcio Infections in patients with chronic lymphocytic leukemia |
title | Infections in patients with chronic lymphocytic leukemia |
title_full | Infections in patients with chronic lymphocytic leukemia |
title_fullStr | Infections in patients with chronic lymphocytic leukemia |
title_full_unstemmed | Infections in patients with chronic lymphocytic leukemia |
title_short | Infections in patients with chronic lymphocytic leukemia |
title_sort | infections in patients with chronic lymphocytic leukemia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499585/ https://www.ncbi.nlm.nih.gov/pubmed/37407362 http://dx.doi.org/10.1016/j.htct.2023.05.006 |
work_keys_str_mv | AT guaranamariana infectionsinpatientswithchroniclymphocyticleukemia AT nuccimarcio infectionsinpatientswithchroniclymphocyticleukemia |