Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle(1). In interphase, DSBs are mainly repaired by non-homologous end...

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Detalles Bibliográficos
Autores principales: Gelot, Camille, Kovacs, Marton Tibor, Miron, Simona, Mylne, Emilie, Haan, Alexis, Boeffard-Dosierre, Liza, Ghouil, Rania, Popova, Tatiana, Dingli, Florent, Loew, Damarys, Guirouilh-Barbat, Josée, Del Nery, Elaine, Zinn-Justin, Sophie, Ceccaldi, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499603/
https://www.ncbi.nlm.nih.gov/pubmed/37674080
http://dx.doi.org/10.1038/s41586-023-06506-6

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