Algorithm for optimized mRNA design improves stability and immunogenicity

Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. (1–3)), but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the vaccine products(4). Increasing secondary s...

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Detalles Bibliográficos
Autores principales: Zhang, He, Zhang, Liang, Lin, Ang, Xu, Congcong, Li, Ziyu, Liu, Kaibo, Liu, Boxiang, Ma, Xiaopin, Zhao, Fanfan, Jiang, Huiling, Chen, Chunxiu, Shen, Haifa, Li, Hangwen, Mathews, David H., Zhang, Yujian, Huang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499610/
https://www.ncbi.nlm.nih.gov/pubmed/37130545
http://dx.doi.org/10.1038/s41586-023-06127-z

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