Targeting neoantigens to APC-surface molecules improves the immunogenicity and anti-tumor efficacy of a DNA cancer vaccine

INTRODUCTION: Tumor-specific mutations generate neoepitopes unique to the cancer that can be recognized by the immune system, making them appealing targets for therapeutic cancer vaccines. Since the vast majority of tumor mutations are patient-specific, it is crucial for cancer vaccine designs to be...

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Detalles Bibliográficos
Autores principales: Barrio-Calvo, Marina, Kofoed, Søren Vester, Holste, Sofie Cens, Sørensen, Anders Bundgård, Viborg, Nadia, Kringelum, Jens Vindahl, Kleine-Kohlbrecher, Daniela, Steenmans, Christian Skjødt, Thygesen, Christian Bahne, Rønø, Birgitte, Friis, Stine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499626/
https://www.ncbi.nlm.nih.gov/pubmed/37720215
http://dx.doi.org/10.3389/fimmu.2023.1234912

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