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BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis

BACKGROUND: Airway inflammation in chronic inflammatory lung diseases (e.g. bronchiectasis) is partly mediated by neutrophil-derived serine protease (NSP)/antiprotease imbalance. NSPs are activated during neutrophil myelopoiesis in bone marrow by cathepsin C (CatC; DPP1). CatC is therefore an attrac...

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Detalles Bibliográficos
Autores principales:	Kreideweiss, Stefan, Schänzle, Gerhard, Schnapp, Gisela, Vintonyak, Viktor, Grundl, Marc A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499737/ https://www.ncbi.nlm.nih.gov/pubmed/37542002 http://dx.doi.org/10.1007/s00011-023-01774-4

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