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Investigating the potential mechanism of quercetin against cervical cancer

BACKGROUND: Cervical cancer is emerging as a potential target of increased susceptibility to coronavirus disease-2019 (COVID-19), leading to compromised survival rates. Despite this critical link, efficacious anti-cervical cancer/COVID-19 interventions remain limited. Quercetin, known for its effica...

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Autores principales: Chu, Man, Ji, Huihui, Li, Kehan, Liu, Hejing, Peng, Mengjia, Wang, Zhiwei, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499770/
https://www.ncbi.nlm.nih.gov/pubmed/37704909
http://dx.doi.org/10.1007/s12672-023-00788-y
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author Chu, Man
Ji, Huihui
Li, Kehan
Liu, Hejing
Peng, Mengjia
Wang, Zhiwei
Zhu, Xueqiong
author_facet Chu, Man
Ji, Huihui
Li, Kehan
Liu, Hejing
Peng, Mengjia
Wang, Zhiwei
Zhu, Xueqiong
author_sort Chu, Man
collection PubMed
description BACKGROUND: Cervical cancer is emerging as a potential target of increased susceptibility to coronavirus disease-2019 (COVID-19), leading to compromised survival rates. Despite this critical link, efficacious anti-cervical cancer/COVID-19 interventions remain limited. Quercetin, known for its efficacy against both cancer and viral infections, holds promise as a therapeutic agent. This study aims to elucidate quercetin’s anti-cervical cancer/COVID-19 mechanisms and potential targets. METHODS: We initiated our investigation with differential gene expression analysis using cervical cancer transcriptome data from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx), focusing on intersections with COVID-19-related genes. Network pharmacology was employed to identify the shared targets between cervical cancer/COVID-19 DEGs and quercetin’s targets. Subsequently, Cox proportional hazards analyses were employed to establish a risk score based on these genes. Molecular docking techniques were applied to predict quercetin’s therapeutic targets and mechanisms for mitigating cervical cancer and COVID-19. RESULTS: Our findings unveiled 45 potential quercetin targets with anti-cervical cancer/COVID-19 actions. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses highlighted significant enrichment in immune pathways and COVID-19-related pathways. A refined risk score model, comprising PLA2G7, TNF, TYK2, F2, and NRP1, effectively stratified cervical cancer patients into distinct risk groups. Importantly, molecular docking analyses illuminated quercetin’s remarkable binding affinity to the primary protease of the coronavirus. CONCLUSIONS: In summation, our study suggests that quercetin holds promise as a potential therapeutic agent for mitigating coronavirus function, specifically through its interaction with the primary protease. This research offers novel insights into exploring COVID-19 susceptibility and enhancing survival in cervical cancer patients.
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spelling pubmed-104997702023-09-15 Investigating the potential mechanism of quercetin against cervical cancer Chu, Man Ji, Huihui Li, Kehan Liu, Hejing Peng, Mengjia Wang, Zhiwei Zhu, Xueqiong Discov Oncol Research BACKGROUND: Cervical cancer is emerging as a potential target of increased susceptibility to coronavirus disease-2019 (COVID-19), leading to compromised survival rates. Despite this critical link, efficacious anti-cervical cancer/COVID-19 interventions remain limited. Quercetin, known for its efficacy against both cancer and viral infections, holds promise as a therapeutic agent. This study aims to elucidate quercetin’s anti-cervical cancer/COVID-19 mechanisms and potential targets. METHODS: We initiated our investigation with differential gene expression analysis using cervical cancer transcriptome data from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx), focusing on intersections with COVID-19-related genes. Network pharmacology was employed to identify the shared targets between cervical cancer/COVID-19 DEGs and quercetin’s targets. Subsequently, Cox proportional hazards analyses were employed to establish a risk score based on these genes. Molecular docking techniques were applied to predict quercetin’s therapeutic targets and mechanisms for mitigating cervical cancer and COVID-19. RESULTS: Our findings unveiled 45 potential quercetin targets with anti-cervical cancer/COVID-19 actions. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses highlighted significant enrichment in immune pathways and COVID-19-related pathways. A refined risk score model, comprising PLA2G7, TNF, TYK2, F2, and NRP1, effectively stratified cervical cancer patients into distinct risk groups. Importantly, molecular docking analyses illuminated quercetin’s remarkable binding affinity to the primary protease of the coronavirus. CONCLUSIONS: In summation, our study suggests that quercetin holds promise as a potential therapeutic agent for mitigating coronavirus function, specifically through its interaction with the primary protease. This research offers novel insights into exploring COVID-19 susceptibility and enhancing survival in cervical cancer patients. Springer US 2023-09-13 /pmc/articles/PMC10499770/ /pubmed/37704909 http://dx.doi.org/10.1007/s12672-023-00788-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Chu, Man
Ji, Huihui
Li, Kehan
Liu, Hejing
Peng, Mengjia
Wang, Zhiwei
Zhu, Xueqiong
Investigating the potential mechanism of quercetin against cervical cancer
title Investigating the potential mechanism of quercetin against cervical cancer
title_full Investigating the potential mechanism of quercetin against cervical cancer
title_fullStr Investigating the potential mechanism of quercetin against cervical cancer
title_full_unstemmed Investigating the potential mechanism of quercetin against cervical cancer
title_short Investigating the potential mechanism of quercetin against cervical cancer
title_sort investigating the potential mechanism of quercetin against cervical cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499770/
https://www.ncbi.nlm.nih.gov/pubmed/37704909
http://dx.doi.org/10.1007/s12672-023-00788-y
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