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TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc

wingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral boundary, and the inner and outer ring domains. tonalli is a trithorax group gene that encodes a putative SUMO E3...

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Autores principales: Rosales-Vega, Marco, Reséndez-Pérez, Diana, Zurita, Mario, Vázquez, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499800/
https://www.ncbi.nlm.nih.gov/pubmed/37704704
http://dx.doi.org/10.1038/s41598-023-42169-z
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author Rosales-Vega, Marco
Reséndez-Pérez, Diana
Zurita, Mario
Vázquez, Martha
author_facet Rosales-Vega, Marco
Reséndez-Pérez, Diana
Zurita, Mario
Vázquez, Martha
author_sort Rosales-Vega, Marco
collection PubMed
description wingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral boundary, and the inner and outer ring domains. tonalli is a trithorax group gene that encodes a putative SUMO E3 ligase that binds to chromatin to regulate the expression of its targets, including the Hox genes. However, its role in modulating gene expression is barely known. Here, we show that TnaA modulates the wingless expression at two domains of the wing disc, the dorso-ventral boundary and the inner ring. At first, tonalli interacts genetically with Notch to form the wing margin. In the inner ring domain, TnaA modulates wingless transcription. When the dosage of TnaA increases in or near the inner ring since early larval stages, this domain expands with a rapid increase in wingless expression. TnaA occupies the wingless Inner Ring Enhancer at the wing disc, meanwhile it does not affect wingless expression directed by the Ventral Disc Enhancer in leg discs, suggesting that TnaA acts as a wingless enhancer-specific factor. We describe for the first time the presence of TnaA at the Inner Ring Enhancer as a specific regulator of wingless in the development of wing boundaries.
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spelling pubmed-104998002023-09-15 TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc Rosales-Vega, Marco Reséndez-Pérez, Diana Zurita, Mario Vázquez, Martha Sci Rep Article wingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral boundary, and the inner and outer ring domains. tonalli is a trithorax group gene that encodes a putative SUMO E3 ligase that binds to chromatin to regulate the expression of its targets, including the Hox genes. However, its role in modulating gene expression is barely known. Here, we show that TnaA modulates the wingless expression at two domains of the wing disc, the dorso-ventral boundary and the inner ring. At first, tonalli interacts genetically with Notch to form the wing margin. In the inner ring domain, TnaA modulates wingless transcription. When the dosage of TnaA increases in or near the inner ring since early larval stages, this domain expands with a rapid increase in wingless expression. TnaA occupies the wingless Inner Ring Enhancer at the wing disc, meanwhile it does not affect wingless expression directed by the Ventral Disc Enhancer in leg discs, suggesting that TnaA acts as a wingless enhancer-specific factor. We describe for the first time the presence of TnaA at the Inner Ring Enhancer as a specific regulator of wingless in the development of wing boundaries. Nature Publishing Group UK 2023-09-13 /pmc/articles/PMC10499800/ /pubmed/37704704 http://dx.doi.org/10.1038/s41598-023-42169-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rosales-Vega, Marco
Reséndez-Pérez, Diana
Zurita, Mario
Vázquez, Martha
TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title_full TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title_fullStr TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title_full_unstemmed TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title_short TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc
title_sort tnaa, a trithorax group protein, modulates wingless expression in different regions of the drosophila wing imaginal disc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499800/
https://www.ncbi.nlm.nih.gov/pubmed/37704704
http://dx.doi.org/10.1038/s41598-023-42169-z
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