Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo

Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by per...

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Detalles Bibliográficos
Autores principales: Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499988/
https://www.ncbi.nlm.nih.gov/pubmed/37704629
http://dx.doi.org/10.1038/s41467-023-41427-y

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