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Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study

OBJECTIVE: White matter hyperintensities (WMH) are commonly seen on T2-weighted magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of cognitive decline and dementia. This study aims to estimate changes in the structural connectome due to age-related WMH by usi...

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Autores principales: Li, Meng, Habes, Mohamad, Grabe, Hans, Kang, Yan, Qi, Shouliang, Detre, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500060/
https://www.ncbi.nlm.nih.gov/pubmed/37719871
http://dx.doi.org/10.3389/fnagi.2023.1237198
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author Li, Meng
Habes, Mohamad
Grabe, Hans
Kang, Yan
Qi, Shouliang
Detre, John A.
author_facet Li, Meng
Habes, Mohamad
Grabe, Hans
Kang, Yan
Qi, Shouliang
Detre, John A.
author_sort Li, Meng
collection PubMed
description OBJECTIVE: White matter hyperintensities (WMH) are commonly seen on T2-weighted magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of cognitive decline and dementia. This study aims to estimate changes in the structural connectome due to age-related WMH by using a virtual lesion approach. METHODS: High-quality diffusion-weighted imaging data of 30 healthy subjects were obtained from the Human Connectome Project (HCP) database. Diffusion tractography using q-space diffeomorphic reconstruction (QSDR) and whole brain fiber tracking with 10(7) seed points was conducted using diffusion spectrum imaging studio and the brainnetome atlas was used to parcellate a total of 246 cortical and subcortical nodes. Previously published WMH frequency maps across age ranges (50’s, 60’s, 70’s, and 80’s) were used to generate virtual lesion masks for each decade at three lesion frequency thresholds, and these virtual lesion masks were applied as regions of avoidance (ROA) in fiber tracking to estimate connectivity changes. Connections showing significant differences in fiber density with and without ROA were identified using paired tests with False Discovery Rate (FDR) correction. RESULTS: Disconnections appeared first from the striatum to middle frontal gyrus (MFG) in the 50’s, then from the thalamus to MFG in the 60’s and extending to the superior frontal gyrus in the 70’s, and ultimately including much more widespread cortical and hippocampal nodes in the 80’s. CONCLUSION: Changes in the structural disconnectome due to age-related WMH can be estimated using the virtual lesion approach. The observed disconnections may contribute to the cognitive and sensorimotor deficits seen in aging.
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spelling pubmed-105000602023-09-15 Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study Li, Meng Habes, Mohamad Grabe, Hans Kang, Yan Qi, Shouliang Detre, John A. Front Aging Neurosci Neuroscience OBJECTIVE: White matter hyperintensities (WMH) are commonly seen on T2-weighted magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of cognitive decline and dementia. This study aims to estimate changes in the structural connectome due to age-related WMH by using a virtual lesion approach. METHODS: High-quality diffusion-weighted imaging data of 30 healthy subjects were obtained from the Human Connectome Project (HCP) database. Diffusion tractography using q-space diffeomorphic reconstruction (QSDR) and whole brain fiber tracking with 10(7) seed points was conducted using diffusion spectrum imaging studio and the brainnetome atlas was used to parcellate a total of 246 cortical and subcortical nodes. Previously published WMH frequency maps across age ranges (50’s, 60’s, 70’s, and 80’s) were used to generate virtual lesion masks for each decade at three lesion frequency thresholds, and these virtual lesion masks were applied as regions of avoidance (ROA) in fiber tracking to estimate connectivity changes. Connections showing significant differences in fiber density with and without ROA were identified using paired tests with False Discovery Rate (FDR) correction. RESULTS: Disconnections appeared first from the striatum to middle frontal gyrus (MFG) in the 50’s, then from the thalamus to MFG in the 60’s and extending to the superior frontal gyrus in the 70’s, and ultimately including much more widespread cortical and hippocampal nodes in the 80’s. CONCLUSION: Changes in the structural disconnectome due to age-related WMH can be estimated using the virtual lesion approach. The observed disconnections may contribute to the cognitive and sensorimotor deficits seen in aging. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10500060/ /pubmed/37719871 http://dx.doi.org/10.3389/fnagi.2023.1237198 Text en Copyright © 2023 Li, Habes, Grabe, Kang, Qi and Detre. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Meng
Habes, Mohamad
Grabe, Hans
Kang, Yan
Qi, Shouliang
Detre, John A.
Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title_full Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title_fullStr Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title_full_unstemmed Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title_short Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
title_sort disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500060/
https://www.ncbi.nlm.nih.gov/pubmed/37719871
http://dx.doi.org/10.3389/fnagi.2023.1237198
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