Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer’s disease

Emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer’s disease (AD). Danger signals including dead neurons, dystrophic axons, phosphorylated tau, and amyloid plaques alter the functi...

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Detalles Bibliográficos
Autores principales: Lopes, Juliana R., Zhang, Xiaoming, Mayrink, Julia, Tatematsu, Bruna K., Guo, Lydia, LeServe, Danielle S., Abou-El-Hassan, Hadi, Rong, Felipe, Dalton, Maria J., Oliveira, Marilia G., Lanser, Toby B., Liu, Lei, Butovsky, Oleg, Rezende, Rafael M., Weiner, Howard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500187/
https://www.ncbi.nlm.nih.gov/pubmed/37669383
http://dx.doi.org/10.1073/pnas.2309221120

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