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Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years

OBJECTIVE: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the pathogenesis. METHODS: In our study, we evaluated t...

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Autores principales: Demirci, Ufuk, Umit, Elif Gulsum, Baysal, Mehmet, Demir, Ahmet Muzaffer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500249/
https://www.ncbi.nlm.nih.gov/pubmed/37719257
http://dx.doi.org/10.14744/nci.2022.57124
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author Demirci, Ufuk
Umit, Elif Gulsum
Baysal, Mehmet
Demir, Ahmet Muzaffer
author_facet Demirci, Ufuk
Umit, Elif Gulsum
Baysal, Mehmet
Demir, Ahmet Muzaffer
author_sort Demirci, Ufuk
collection PubMed
description OBJECTIVE: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the pathogenesis. METHODS: In our study, we evaluated the features of 33 patients with ITP, over 80 years of age. RESULTS: The median age of the patients was 90, 15 patients were female (45.4%). The mean platelet count of the patients was 39×10(9)/L and the mean mean platelet volume was 10,33fL. Twelve patients had a target thrombocyte count greater than 30×10(9)/L, while 20 patients had a target platelet count of 75×10(9)/L or greater with an absolute indication of antiaggregation. In the environmental spread, 18 dysplasia findings were observed. CONCLUSION: Morphologic observations suggesting dysplasia including micromegakaryocytes and a non-dysplastic but dysmegakaryopoietic finding, multiple segmented nuclei may be related to the degree of thrombocytopenia and response to treatment. Likewise, nondysplastic features including immature forms, emperipolesis, bare nucleus, hypolobulation, and hypersegmented nucleus were related to the degree of thrombocytopenia.
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spelling pubmed-105002492023-09-15 Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years Demirci, Ufuk Umit, Elif Gulsum Baysal, Mehmet Demir, Ahmet Muzaffer North Clin Istanb Original Article OBJECTIVE: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the pathogenesis. METHODS: In our study, we evaluated the features of 33 patients with ITP, over 80 years of age. RESULTS: The median age of the patients was 90, 15 patients were female (45.4%). The mean platelet count of the patients was 39×10(9)/L and the mean mean platelet volume was 10,33fL. Twelve patients had a target thrombocyte count greater than 30×10(9)/L, while 20 patients had a target platelet count of 75×10(9)/L or greater with an absolute indication of antiaggregation. In the environmental spread, 18 dysplasia findings were observed. CONCLUSION: Morphologic observations suggesting dysplasia including micromegakaryocytes and a non-dysplastic but dysmegakaryopoietic finding, multiple segmented nuclei may be related to the degree of thrombocytopenia and response to treatment. Likewise, nondysplastic features including immature forms, emperipolesis, bare nucleus, hypolobulation, and hypersegmented nucleus were related to the degree of thrombocytopenia. Kare Publishing 2023-08-09 /pmc/articles/PMC10500249/ /pubmed/37719257 http://dx.doi.org/10.14744/nci.2022.57124 Text en © Copyright 2023 by Istanbul Provincial Directorate of Health https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Demirci, Ufuk
Umit, Elif Gulsum
Baysal, Mehmet
Demir, Ahmet Muzaffer
Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title_full Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title_fullStr Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title_full_unstemmed Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title_short Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
title_sort morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500249/
https://www.ncbi.nlm.nih.gov/pubmed/37719257
http://dx.doi.org/10.14744/nci.2022.57124
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