Modest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability

Chromosomal instability (CIN), the process of increased chromosomal alterations, compromises genomic integrity and has profound consequences on human health. Yet, our understanding of the molecular and mechanistic basis of CIN initiation remains limited. We developed a high-throughput, single-cell,...

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Detalles Bibliográficos
Autores principales: Dale, Katie L., Armond, Jonathan W., Hynds, Robert E., Vladimirou, Elina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500341/
https://www.ncbi.nlm.nih.gov/pubmed/35929456
http://dx.doi.org/10.1242/jcs.260031

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