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Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma

We aimed to investigate the association between iodine intake and nodal metastasis stratified by central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) of papillary thyroid microcarcinoma (PTMC). Urinary iodine concentration (UIC) and clinicopathological characteristics were u...

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Autores principales: Zhao, Hengqiang, Hu, Jin, Cui, Le, Gong, Yiping, Huang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500345/
https://www.ncbi.nlm.nih.gov/pubmed/37720525
http://dx.doi.org/10.3389/fendo.2023.1164069
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author Zhao, Hengqiang
Hu, Jin
Cui, Le
Gong, Yiping
Huang, Tao
author_facet Zhao, Hengqiang
Hu, Jin
Cui, Le
Gong, Yiping
Huang, Tao
author_sort Zhao, Hengqiang
collection PubMed
description We aimed to investigate the association between iodine intake and nodal metastasis stratified by central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) of papillary thyroid microcarcinoma (PTMC). Urinary iodine concentration (UIC) and clinicopathological characteristics were used to identify factors associated with CLNM and LLNM using logistic regression analysis. A sum of 3,858 PTMC patients were enrolled. The median UIC (MUI) of patients with CLNM or LLNM was not statistically different from those without nodal metastasis. Male patients had a higher MUI than females (183.4 μg/L vs. 173.6 μg/L). Female patients with extracapsular extension had a higher MUI than those without it (210.0 μg/L vs. 172.1 μg/L). Male patients with LLNM had a significantly lower MUI than those without LLNM (134.7 μg/L vs. 187.9 μg/L). Female patients with more than adequate iodine intake were more likely to present with CLNM and extrathyroidal extension than those with adequate iodine intake with an odds ratio (95% confidence interval) of 1.23 (1.01–1.51) and 1.59 (1.09–2.32) after adjustment. Iodine nutrition was not found to be associated with LLNM. In addition, patients with a younger age, larger tumors, extrathyroidal extension, and intrathyroidal spread were more likely to be CLNM, whereas nodular goiter presented with a protective factor; CLNM was the only factor associated with LLNM of PTMC in both genders. In conclusion, iodine nutrition has a much closer association with female than male patients, and high iodine intake may be associated with CLNM and extrathyroidal extension in female PTMC patients.
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spelling pubmed-105003452023-09-15 Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma Zhao, Hengqiang Hu, Jin Cui, Le Gong, Yiping Huang, Tao Front Endocrinol (Lausanne) Endocrinology We aimed to investigate the association between iodine intake and nodal metastasis stratified by central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) of papillary thyroid microcarcinoma (PTMC). Urinary iodine concentration (UIC) and clinicopathological characteristics were used to identify factors associated with CLNM and LLNM using logistic regression analysis. A sum of 3,858 PTMC patients were enrolled. The median UIC (MUI) of patients with CLNM or LLNM was not statistically different from those without nodal metastasis. Male patients had a higher MUI than females (183.4 μg/L vs. 173.6 μg/L). Female patients with extracapsular extension had a higher MUI than those without it (210.0 μg/L vs. 172.1 μg/L). Male patients with LLNM had a significantly lower MUI than those without LLNM (134.7 μg/L vs. 187.9 μg/L). Female patients with more than adequate iodine intake were more likely to present with CLNM and extrathyroidal extension than those with adequate iodine intake with an odds ratio (95% confidence interval) of 1.23 (1.01–1.51) and 1.59 (1.09–2.32) after adjustment. Iodine nutrition was not found to be associated with LLNM. In addition, patients with a younger age, larger tumors, extrathyroidal extension, and intrathyroidal spread were more likely to be CLNM, whereas nodular goiter presented with a protective factor; CLNM was the only factor associated with LLNM of PTMC in both genders. In conclusion, iodine nutrition has a much closer association with female than male patients, and high iodine intake may be associated with CLNM and extrathyroidal extension in female PTMC patients. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10500345/ /pubmed/37720525 http://dx.doi.org/10.3389/fendo.2023.1164069 Text en Copyright © 2023 Zhao, Hu, Cui, Gong and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhao, Hengqiang
Hu, Jin
Cui, Le
Gong, Yiping
Huang, Tao
Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title_full Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title_fullStr Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title_full_unstemmed Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title_short Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
title_sort association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500345/
https://www.ncbi.nlm.nih.gov/pubmed/37720525
http://dx.doi.org/10.3389/fendo.2023.1164069
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