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Abnormal temporal variability of rich-club organization in three major psychiatric conditions

INTRODUCTION: Convergent evidence has demonstrated a shared rich-club reorganization across multiple major psychiatric conditions. However, previous studies assessing altered functional couplings between rich-club regions have typically focused on the mean time series from entire functional magnetic...

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Autores principales: Niu, Meng, Guo, Hanning, Zhang, Zhe, Fu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500439/
https://www.ncbi.nlm.nih.gov/pubmed/37720902
http://dx.doi.org/10.3389/fpsyt.2023.1226143
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author Niu, Meng
Guo, Hanning
Zhang, Zhe
Fu, Yu
author_facet Niu, Meng
Guo, Hanning
Zhang, Zhe
Fu, Yu
author_sort Niu, Meng
collection PubMed
description INTRODUCTION: Convergent evidence has demonstrated a shared rich-club reorganization across multiple major psychiatric conditions. However, previous studies assessing altered functional couplings between rich-club regions have typically focused on the mean time series from entire functional magnetic resonance imaging (fMRI) scanning session, neglecting their time-varying properties. METHODS: In this study, we aim to explore the common and/or unique alterations in the temporal variability of rich-club organization among schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). We employed a temporal rich-club (TRC) approach to quantitatively assess the propensity of well-connected nodes to form simultaneous and stable structures in a temporal network derived from resting-state fMRI data of 156 patients with major psychiatric disorders (SZ/BD/ADHD = 71/45/40) and 172 healthy controls. We executed the TRC workflow at both whole-brain and subnetwork scales across varying network sparsity, sliding window strategies, lengths and steps of sliding windows, and durations of TRC coefficients. RESULTS: The SZ and BD groups displayed significantly decreased TRC coefficients compared to corresponding HC groups at the whole-brain scale and in most subnetworks. In contrast, the ADHD group exhibited reduced TRC coefficients in longer durations, as opposed to shorter durations, which markedly differs from the SZ and BD groups. These findings reveal both transdiagnostic and illness-specific patterns in temporal variability of rich-club organization across SZ, BD, and ADHD. DISCUSSION: TRC may serve as an effective metric for detecting brain network disruptions in particular states, offering novel insights and potential biomarkers into the neurobiological basis underpinning the behavioral and cognitive deficits observed in these disorders.
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spelling pubmed-105004392023-09-15 Abnormal temporal variability of rich-club organization in three major psychiatric conditions Niu, Meng Guo, Hanning Zhang, Zhe Fu, Yu Front Psychiatry Psychiatry INTRODUCTION: Convergent evidence has demonstrated a shared rich-club reorganization across multiple major psychiatric conditions. However, previous studies assessing altered functional couplings between rich-club regions have typically focused on the mean time series from entire functional magnetic resonance imaging (fMRI) scanning session, neglecting their time-varying properties. METHODS: In this study, we aim to explore the common and/or unique alterations in the temporal variability of rich-club organization among schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). We employed a temporal rich-club (TRC) approach to quantitatively assess the propensity of well-connected nodes to form simultaneous and stable structures in a temporal network derived from resting-state fMRI data of 156 patients with major psychiatric disorders (SZ/BD/ADHD = 71/45/40) and 172 healthy controls. We executed the TRC workflow at both whole-brain and subnetwork scales across varying network sparsity, sliding window strategies, lengths and steps of sliding windows, and durations of TRC coefficients. RESULTS: The SZ and BD groups displayed significantly decreased TRC coefficients compared to corresponding HC groups at the whole-brain scale and in most subnetworks. In contrast, the ADHD group exhibited reduced TRC coefficients in longer durations, as opposed to shorter durations, which markedly differs from the SZ and BD groups. These findings reveal both transdiagnostic and illness-specific patterns in temporal variability of rich-club organization across SZ, BD, and ADHD. DISCUSSION: TRC may serve as an effective metric for detecting brain network disruptions in particular states, offering novel insights and potential biomarkers into the neurobiological basis underpinning the behavioral and cognitive deficits observed in these disorders. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10500439/ /pubmed/37720902 http://dx.doi.org/10.3389/fpsyt.2023.1226143 Text en Copyright © 2023 Niu, Guo, Zhang and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Niu, Meng
Guo, Hanning
Zhang, Zhe
Fu, Yu
Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title_full Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title_fullStr Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title_full_unstemmed Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title_short Abnormal temporal variability of rich-club organization in three major psychiatric conditions
title_sort abnormal temporal variability of rich-club organization in three major psychiatric conditions
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500439/
https://www.ncbi.nlm.nih.gov/pubmed/37720902
http://dx.doi.org/10.3389/fpsyt.2023.1226143
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