Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we d...

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Autores principales: Seada, Samy Abo, van der Eerden, Anke W., Boon, Agnita J.W., Hernandez-Tamames, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500558/
https://www.ncbi.nlm.nih.gov/pubmed/37696098
http://dx.doi.org/10.1016/j.nicl.2023.103506
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author Seada, Samy Abo
van der Eerden, Anke W.
Boon, Agnita J.W.
Hernandez-Tamames, Juan A.
author_facet Seada, Samy Abo
van der Eerden, Anke W.
Boon, Agnita J.W.
Hernandez-Tamames, Juan A.
author_sort Seada, Samy Abo
collection PubMed
description Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.
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spelling pubmed-105005582023-09-15 Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design Seada, Samy Abo van der Eerden, Anke W. Boon, Agnita J.W. Hernandez-Tamames, Juan A. Neuroimage Clin Review Article Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature. Elsevier 2023-09-09 /pmc/articles/PMC10500558/ /pubmed/37696098 http://dx.doi.org/10.1016/j.nicl.2023.103506 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Seada, Samy Abo
van der Eerden, Anke W.
Boon, Agnita J.W.
Hernandez-Tamames, Juan A.
Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title_full Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title_fullStr Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title_full_unstemmed Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title_short Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
title_sort quantitative mri protocol and decision model for a ‘one stop shop’ early-stage parkinsonism diagnosis: study design
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500558/
https://www.ncbi.nlm.nih.gov/pubmed/37696098
http://dx.doi.org/10.1016/j.nicl.2023.103506
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