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Probing the Activation Mechanisms of Agonist DPI-287 to Delta-Opioid Receptor and Novel Agonists Using Ensemble-Based Virtual Screening with Molecular Dynamics Simulations

[Image: see text] Pain drugs targeting mu-opioid receptors face major addiction problems that have caused an epidemic. The delta-opioid receptor (DOR) has shown to not cause addictive effects when bound to an agonist. While the active conformation of the DOR in complex with agonist DPI-287 has been...

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Detalles Bibliográficos
Autores principales:	Dean, Emily, Dominique, AnneMarie, Palillero, Americus, Tran, Annie, Paradis, Nicholas, Wu, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500586/ https://www.ncbi.nlm.nih.gov/pubmed/37720760 http://dx.doi.org/10.1021/acsomega.3c01918

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