Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis

Anti-tumor necrosis factor-alpha (TNF-⍺) inhibitors are commonly used in the treatment of inflammatory conditions such as psoriasis. However, these agents lead to increased susceptibility to infections. We report a patient with reactivation of latent histoplasmosis six months after starting an anti-...

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Detalles Bibliográficos
Autores principales: Harrison, Iris, Forouzandeh, Mahtab, Motaparthi, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500618/
https://www.ncbi.nlm.nih.gov/pubmed/37720115
http://dx.doi.org/10.7759/cureus.45217
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author Harrison, Iris
Forouzandeh, Mahtab
Motaparthi, Kiran
author_facet Harrison, Iris
Forouzandeh, Mahtab
Motaparthi, Kiran
author_sort Harrison, Iris
collection PubMed
description Anti-tumor necrosis factor-alpha (TNF-⍺) inhibitors are commonly used in the treatment of inflammatory conditions such as psoriasis. However, these agents lead to increased susceptibility to infections. We report a patient with reactivation of latent histoplasmosis six months after starting an anti-TNF-⍺ inhibitor for the treatment of psoriasis. Dermatologists should be aware of the risks associated with initiating therapy and maintain a low threshold of suspicion for this infection in patients on anti-TNF-⍺ inhibitors presenting with oral ulcers.
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spelling pubmed-105006182023-09-15 Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis Harrison, Iris Forouzandeh, Mahtab Motaparthi, Kiran Cureus Dermatology Anti-tumor necrosis factor-alpha (TNF-⍺) inhibitors are commonly used in the treatment of inflammatory conditions such as psoriasis. However, these agents lead to increased susceptibility to infections. We report a patient with reactivation of latent histoplasmosis six months after starting an anti-TNF-⍺ inhibitor for the treatment of psoriasis. Dermatologists should be aware of the risks associated with initiating therapy and maintain a low threshold of suspicion for this infection in patients on anti-TNF-⍺ inhibitors presenting with oral ulcers. Cureus 2023-09-14 /pmc/articles/PMC10500618/ /pubmed/37720115 http://dx.doi.org/10.7759/cureus.45217 Text en Copyright © 2023, Harrison et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Harrison, Iris
Forouzandeh, Mahtab
Motaparthi, Kiran
Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title_full Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title_fullStr Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title_full_unstemmed Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title_short Chronic Ulcer on the Tongue as a Manifestation of Histoplasmosis During Anti-tumor Necrosis Factor-Alpha (TNF-⍺) Inhibitor Therapy for Psoriasis
title_sort chronic ulcer on the tongue as a manifestation of histoplasmosis during anti-tumor necrosis factor-alpha (tnf-⍺) inhibitor therapy for psoriasis
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500618/
https://www.ncbi.nlm.nih.gov/pubmed/37720115
http://dx.doi.org/10.7759/cureus.45217
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