Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling

[Image: see text] This work presents a flexible synthesis of 10 novel naphthoquinone–chalcone derivatives (1–10) by nucleophilic substitution of readily accessible aminochalcones and 2,3-dichloro-1,4-naphthoquinone. All compounds displayed broad-spectrum cytotoxic activities against all the tested c...

Descripción completa

Detalles Bibliográficos
Autores principales: Leechaisit, Ronnakorn, Mahalapbutr, Panupong, Boonsri, Pornthip, Karnchanapandh, Kun, Rungrotmongkol, Thanyada, Prachayasittikul, Veda, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong, Pingaew, Ratchanok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500653/
https://www.ncbi.nlm.nih.gov/pubmed/37720749
http://dx.doi.org/10.1021/acsomega.3c03176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500653/
https://www.ncbi.nlm.nih.gov/pubmed/37720749
http://dx.doi.org/10.1021/acsomega.3c03176

Ejemplares similares