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Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the diseas...

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Autores principales: Huang, Chunjie, Azizi, Paniz, Vazirzadeh, Masoud, Aghaei-Zarch, Seyed Mohsen, Aghaei-Zarch, Fatemehsadat, Ghanavi, Jalaledin, Farnia, Poopak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500757/
https://www.ncbi.nlm.nih.gov/pubmed/37705098
http://dx.doi.org/10.1186/s12967-023-04510-y
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author Huang, Chunjie
Azizi, Paniz
Vazirzadeh, Masoud
Aghaei-Zarch, Seyed Mohsen
Aghaei-Zarch, Fatemehsadat
Ghanavi, Jalaledin
Farnia, Poopak
author_facet Huang, Chunjie
Azizi, Paniz
Vazirzadeh, Masoud
Aghaei-Zarch, Seyed Mohsen
Aghaei-Zarch, Fatemehsadat
Ghanavi, Jalaledin
Farnia, Poopak
author_sort Huang, Chunjie
collection PubMed
description Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the disease’s progression. The human cancer condition involves dysregulation of the DNA methyltransferase 3 beta (DNMT3B) gene, a prominent de novo DNA methyltransferase, and its abnormal behavior serves as an indicator for tumor prognosis and staging. The expression of non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), is critical in controlling targeted gene expression and protein translation and their dysregulation correlates with the onset of tumors. NcRNAs dysregulation of is a critical factor that influences the modulation of several cellular characteristics in cancerous cells. These characteristics include but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, and properties of tumor stem cell. The reciprocal regulation of ncRNAs and DNMT3B can act in synergy to influence the destiny of tumor cells. Thus, a critical avenue for advancing cancer prevention and treatment is an inquiry into the interplay between DNMT3B and ncRNAs. In this review, we present a comprehensive overview of the ncRNAs/DNMT3B axis in cancer pathogenesis. This brings about valuable insights into the intricate mechanisms of tumorigenesis and provides a foundation for developing effective therapeutic interventions.
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spelling pubmed-105007572023-09-15 Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance Huang, Chunjie Azizi, Paniz Vazirzadeh, Masoud Aghaei-Zarch, Seyed Mohsen Aghaei-Zarch, Fatemehsadat Ghanavi, Jalaledin Farnia, Poopak J Transl Med Review Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the disease’s progression. The human cancer condition involves dysregulation of the DNA methyltransferase 3 beta (DNMT3B) gene, a prominent de novo DNA methyltransferase, and its abnormal behavior serves as an indicator for tumor prognosis and staging. The expression of non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), is critical in controlling targeted gene expression and protein translation and their dysregulation correlates with the onset of tumors. NcRNAs dysregulation of is a critical factor that influences the modulation of several cellular characteristics in cancerous cells. These characteristics include but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, and properties of tumor stem cell. The reciprocal regulation of ncRNAs and DNMT3B can act in synergy to influence the destiny of tumor cells. Thus, a critical avenue for advancing cancer prevention and treatment is an inquiry into the interplay between DNMT3B and ncRNAs. In this review, we present a comprehensive overview of the ncRNAs/DNMT3B axis in cancer pathogenesis. This brings about valuable insights into the intricate mechanisms of tumorigenesis and provides a foundation for developing effective therapeutic interventions. BioMed Central 2023-09-13 /pmc/articles/PMC10500757/ /pubmed/37705098 http://dx.doi.org/10.1186/s12967-023-04510-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Chunjie
Azizi, Paniz
Vazirzadeh, Masoud
Aghaei-Zarch, Seyed Mohsen
Aghaei-Zarch, Fatemehsadat
Ghanavi, Jalaledin
Farnia, Poopak
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title_full Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title_fullStr Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title_full_unstemmed Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title_short Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
title_sort non-coding rnas/dnmt3b axis in human cancers: from pathogenesis to clinical significance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500757/
https://www.ncbi.nlm.nih.gov/pubmed/37705098
http://dx.doi.org/10.1186/s12967-023-04510-y
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