Biological roles of RNA m7G modification and its implications in cancer

M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions hav...

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Autores principales: Zhang, Xin, Zhu, Wen-Yan, Shen, Shu-Yi, Shen, Jia-Hao, Chen, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500781/
https://www.ncbi.nlm.nih.gov/pubmed/37710294
http://dx.doi.org/10.1186/s13062-023-00414-5
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author Zhang, Xin
Zhu, Wen-Yan
Shen, Shu-Yi
Shen, Jia-Hao
Chen, Xiao-Dong
author_facet Zhang, Xin
Zhu, Wen-Yan
Shen, Shu-Yi
Shen, Jia-Hao
Chen, Xiao-Dong
author_sort Zhang, Xin
collection PubMed
description M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research’s future directions and trends.
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spelling pubmed-105007812023-09-15 Biological roles of RNA m7G modification and its implications in cancer Zhang, Xin Zhu, Wen-Yan Shen, Shu-Yi Shen, Jia-Hao Chen, Xiao-Dong Biol Direct Review M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research’s future directions and trends. BioMed Central 2023-09-14 /pmc/articles/PMC10500781/ /pubmed/37710294 http://dx.doi.org/10.1186/s13062-023-00414-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Xin
Zhu, Wen-Yan
Shen, Shu-Yi
Shen, Jia-Hao
Chen, Xiao-Dong
Biological roles of RNA m7G modification and its implications in cancer
title Biological roles of RNA m7G modification and its implications in cancer
title_full Biological roles of RNA m7G modification and its implications in cancer
title_fullStr Biological roles of RNA m7G modification and its implications in cancer
title_full_unstemmed Biological roles of RNA m7G modification and its implications in cancer
title_short Biological roles of RNA m7G modification and its implications in cancer
title_sort biological roles of rna m7g modification and its implications in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500781/
https://www.ncbi.nlm.nih.gov/pubmed/37710294
http://dx.doi.org/10.1186/s13062-023-00414-5
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