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SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes

BACKGROUND: Cardiovascular complications significantly augment the overall COVID-19 mortality, largely due to the susceptibility of human cardiomyocytes (CMs) to SARS-CoV-2 virus. SARS-CoV-2 virus encodes 27 genes, whose specific impacts on CM health are not fully understood. This study elucidates t...

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Detalles Bibliográficos
Autores principales:	Liu, Juli, Wu, Shiyong, Zhang, Yucheng, Wang, Cheng, Liu, Sheng, Wan, Jun, Yang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500938/ https://www.ncbi.nlm.nih.gov/pubmed/37705046 http://dx.doi.org/10.1186/s13287-023-03485-3

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