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Disseminated BCG infection revealing a severe combined immunodeficiency: A case report
Introduction: Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in Tunisia, can lead to serious complications ranging from local disease to disseminated disease in a group of patients with primary immunodeficiency diseases. Case report: A 3-month-old boy presented with pe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tunisian Society of Medical Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501126/ https://www.ncbi.nlm.nih.gov/pubmed/37551538 |
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author | Ben Belgacem, Hajer Bouguila, Jihene Tej, Amel Tilouche, Samia Kebaili, Raoudha Kahloul, Najoua Barbouche, Mohamed Ridha Soyah, Nejla Boughammoura, Lamia |
author_facet | Ben Belgacem, Hajer Bouguila, Jihene Tej, Amel Tilouche, Samia Kebaili, Raoudha Kahloul, Najoua Barbouche, Mohamed Ridha Soyah, Nejla Boughammoura, Lamia |
author_sort | Ben Belgacem, Hajer |
collection | PubMed |
description | Introduction: Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in Tunisia, can lead to serious complications ranging from local disease to disseminated disease in a group of patients with primary immunodeficiency diseases. Case report: A 3-month-old boy presented with persistent fever, hepato-splenomegaly and multiple osteolytic lesions. He was diagnosed with severe combined immunodeficiency disease and disseminated BCG infection. Despite anti-tubercular therapy combined with intravenous immunoglobulin, the evolution was fatal. Conclusion: The case highlights the possible risk of such rare yet lethal complication of BCG vaccine. In suspected cases of primary immunodeficiency disease, inoculation of BCG should be postponed until appropriate screening tests exclude such diagnosis to prevent serious complications. |
format | Online Article Text |
id | pubmed-10501126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Tunisian Society of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-105011262023-09-15 Disseminated BCG infection revealing a severe combined immunodeficiency: A case report Ben Belgacem, Hajer Bouguila, Jihene Tej, Amel Tilouche, Samia Kebaili, Raoudha Kahloul, Najoua Barbouche, Mohamed Ridha Soyah, Nejla Boughammoura, Lamia Tunis Med Article Introduction: Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in Tunisia, can lead to serious complications ranging from local disease to disseminated disease in a group of patients with primary immunodeficiency diseases. Case report: A 3-month-old boy presented with persistent fever, hepato-splenomegaly and multiple osteolytic lesions. He was diagnosed with severe combined immunodeficiency disease and disseminated BCG infection. Despite anti-tubercular therapy combined with intravenous immunoglobulin, the evolution was fatal. Conclusion: The case highlights the possible risk of such rare yet lethal complication of BCG vaccine. In suspected cases of primary immunodeficiency disease, inoculation of BCG should be postponed until appropriate screening tests exclude such diagnosis to prevent serious complications. Tunisian Society of Medical Sciences 2022-12 2022-12-01 /pmc/articles/PMC10501126/ /pubmed/37551538 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Article Ben Belgacem, Hajer Bouguila, Jihene Tej, Amel Tilouche, Samia Kebaili, Raoudha Kahloul, Najoua Barbouche, Mohamed Ridha Soyah, Nejla Boughammoura, Lamia Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title | Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title_full | Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title_fullStr | Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title_full_unstemmed | Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title_short | Disseminated BCG infection revealing a severe combined immunodeficiency: A case report |
title_sort | disseminated bcg infection revealing a severe combined immunodeficiency: a case report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501126/ https://www.ncbi.nlm.nih.gov/pubmed/37551538 |
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