Cargando…
Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection
BACKGROUND: The influencing factors, especially time to treatment (TTT), for T1b/T2 gallbladder cancer (GBC) patients remain unknown. We aimed to identify the influencing factors on survival and surgical approaches selection for T1b/T2 GBC. METHODS: We retrospectively screened GBC patients between J...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501227/ https://www.ncbi.nlm.nih.gov/pubmed/37366278 http://dx.doi.org/10.1002/cam4.6297 |
_version_ | 1785106074879131648 |
---|---|
author | Cao, Jiasheng Yan, Jiafei Hu, Jiahao Zhang, Bin Topatana, Win Li, Shijie Chen, Tianen Jeungpanich, Sarun Lu, Ziyi Peng, Shuyou Cai, Xiujun Chen, Mingyu |
author_facet | Cao, Jiasheng Yan, Jiafei Hu, Jiahao Zhang, Bin Topatana, Win Li, Shijie Chen, Tianen Jeungpanich, Sarun Lu, Ziyi Peng, Shuyou Cai, Xiujun Chen, Mingyu |
author_sort | Cao, Jiasheng |
collection | PubMed |
description | BACKGROUND: The influencing factors, especially time to treatment (TTT), for T1b/T2 gallbladder cancer (GBC) patients remain unknown. We aimed to identify the influencing factors on survival and surgical approaches selection for T1b/T2 GBC. METHODS: We retrospectively screened GBC patients between January 2011 and August 2018 from our hospital. Clinical variables, including patient characteristics, TTT, overall survival (OS), disease‐free survival (DFS), surgery‐related outcomes, and surgical approaches were collected. RESULTS: A total of 114 T1b/T2 GBC patients who underwent radical resection were included. Based on the median TTT of 7.5 days, the study cohort was divided into short TTT group (TTT ≤7 days, n = 57) and long TTT group (TTT >7 days, n = 57). Referrals were identified as the primary factor prolonging TTT (p < 0.001). There was no significance in OS (p = 0.790), DFS (p = 0.580), and surgery‐related outcomes (all p > 0.05) between both groups. Decreased referrals (p = 0.005), fewer positive lymph nodes (LNs; p = 0.004), and well tumor differentiation (p = 0.004) were all associated with better OS, while fewer positive LNs (p = 0.049) were associated with better DFS. Subgroup analyses revealed no significant difference in survival between patients undergoing laparoscopic or open approach in different TTT groups (all p > 0.05). And secondary subgroup analyses found no significance in survival and surgery‐related outcomes between different TTT groups of incidental GBC patients (all p > 0.05). CONCLUSIONS: Positive LNs and tumor differentiation were prognostic factors for T1b/T2 GBC survival. Referrals associating with poor OS would delay TTT, while the prolonged TTT would not impact survival, surgery‐related outcomes, and surgical approaches decisions in T1b/T2 GBC patients. |
format | Online Article Text |
id | pubmed-10501227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105012272023-09-15 Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection Cao, Jiasheng Yan, Jiafei Hu, Jiahao Zhang, Bin Topatana, Win Li, Shijie Chen, Tianen Jeungpanich, Sarun Lu, Ziyi Peng, Shuyou Cai, Xiujun Chen, Mingyu Cancer Med RESEARCH ARTICLES BACKGROUND: The influencing factors, especially time to treatment (TTT), for T1b/T2 gallbladder cancer (GBC) patients remain unknown. We aimed to identify the influencing factors on survival and surgical approaches selection for T1b/T2 GBC. METHODS: We retrospectively screened GBC patients between January 2011 and August 2018 from our hospital. Clinical variables, including patient characteristics, TTT, overall survival (OS), disease‐free survival (DFS), surgery‐related outcomes, and surgical approaches were collected. RESULTS: A total of 114 T1b/T2 GBC patients who underwent radical resection were included. Based on the median TTT of 7.5 days, the study cohort was divided into short TTT group (TTT ≤7 days, n = 57) and long TTT group (TTT >7 days, n = 57). Referrals were identified as the primary factor prolonging TTT (p < 0.001). There was no significance in OS (p = 0.790), DFS (p = 0.580), and surgery‐related outcomes (all p > 0.05) between both groups. Decreased referrals (p = 0.005), fewer positive lymph nodes (LNs; p = 0.004), and well tumor differentiation (p = 0.004) were all associated with better OS, while fewer positive LNs (p = 0.049) were associated with better DFS. Subgroup analyses revealed no significant difference in survival between patients undergoing laparoscopic or open approach in different TTT groups (all p > 0.05). And secondary subgroup analyses found no significance in survival and surgery‐related outcomes between different TTT groups of incidental GBC patients (all p > 0.05). CONCLUSIONS: Positive LNs and tumor differentiation were prognostic factors for T1b/T2 GBC survival. Referrals associating with poor OS would delay TTT, while the prolonged TTT would not impact survival, surgery‐related outcomes, and surgical approaches decisions in T1b/T2 GBC patients. John Wiley and Sons Inc. 2023-06-27 /pmc/articles/PMC10501227/ /pubmed/37366278 http://dx.doi.org/10.1002/cam4.6297 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Cao, Jiasheng Yan, Jiafei Hu, Jiahao Zhang, Bin Topatana, Win Li, Shijie Chen, Tianen Jeungpanich, Sarun Lu, Ziyi Peng, Shuyou Cai, Xiujun Chen, Mingyu Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title | Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title_full | Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title_fullStr | Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title_full_unstemmed | Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title_short | Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection |
title_sort | estimating the influencing factors for t1b/t2 gallbladder cancer on survival and surgical approaches selection |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501227/ https://www.ncbi.nlm.nih.gov/pubmed/37366278 http://dx.doi.org/10.1002/cam4.6297 |
work_keys_str_mv | AT caojiasheng estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT yanjiafei estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT hujiahao estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT zhangbin estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT topatanawin estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT lishijie estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT chentianen estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT jeungpanichsarun estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT luziyi estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT pengshuyou estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT caixiujun estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection AT chenmingyu estimatingtheinfluencingfactorsfort1bt2gallbladdercanceronsurvivalandsurgicalapproachesselection |