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Frontline clinical diagnosis—FTIR on pancreatic cancer

OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectrosco...

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Detalles Bibliográficos
Autores principales: Duckworth, Edward, Mortimer, Matthew, Al‐Sarireh, Bilal, Kanamarlapudi, Venkateswarlu, Roy, Debdulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501286/
https://www.ncbi.nlm.nih.gov/pubmed/37466344
http://dx.doi.org/10.1002/cam4.6346
Descripción
Sumario:OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. RESULTS: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet‐spots within blood plasma fractions containing molecules within a narrow range of molecular weights.