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Frontline clinical diagnosis—FTIR on pancreatic cancer

OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectrosco...

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Autores principales: Duckworth, Edward, Mortimer, Matthew, Al‐Sarireh, Bilal, Kanamarlapudi, Venkateswarlu, Roy, Debdulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501286/
https://www.ncbi.nlm.nih.gov/pubmed/37466344
http://dx.doi.org/10.1002/cam4.6346
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author Duckworth, Edward
Mortimer, Matthew
Al‐Sarireh, Bilal
Kanamarlapudi, Venkateswarlu
Roy, Debdulal
author_facet Duckworth, Edward
Mortimer, Matthew
Al‐Sarireh, Bilal
Kanamarlapudi, Venkateswarlu
Roy, Debdulal
author_sort Duckworth, Edward
collection PubMed
description OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. RESULTS: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet‐spots within blood plasma fractions containing molecules within a narrow range of molecular weights.
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spelling pubmed-105012862023-09-15 Frontline clinical diagnosis—FTIR on pancreatic cancer Duckworth, Edward Mortimer, Matthew Al‐Sarireh, Bilal Kanamarlapudi, Venkateswarlu Roy, Debdulal Cancer Med RESEARCH ARTICLES OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. RESULTS: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet‐spots within blood plasma fractions containing molecules within a narrow range of molecular weights. John Wiley and Sons Inc. 2023-07-19 /pmc/articles/PMC10501286/ /pubmed/37466344 http://dx.doi.org/10.1002/cam4.6346 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Duckworth, Edward
Mortimer, Matthew
Al‐Sarireh, Bilal
Kanamarlapudi, Venkateswarlu
Roy, Debdulal
Frontline clinical diagnosis—FTIR on pancreatic cancer
title Frontline clinical diagnosis—FTIR on pancreatic cancer
title_full Frontline clinical diagnosis—FTIR on pancreatic cancer
title_fullStr Frontline clinical diagnosis—FTIR on pancreatic cancer
title_full_unstemmed Frontline clinical diagnosis—FTIR on pancreatic cancer
title_short Frontline clinical diagnosis—FTIR on pancreatic cancer
title_sort frontline clinical diagnosis—ftir on pancreatic cancer
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501286/
https://www.ncbi.nlm.nih.gov/pubmed/37466344
http://dx.doi.org/10.1002/cam4.6346
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