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Frontline clinical diagnosis—FTIR on pancreatic cancer
OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectrosco...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501286/ https://www.ncbi.nlm.nih.gov/pubmed/37466344 http://dx.doi.org/10.1002/cam4.6346 |
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author | Duckworth, Edward Mortimer, Matthew Al‐Sarireh, Bilal Kanamarlapudi, Venkateswarlu Roy, Debdulal |
author_facet | Duckworth, Edward Mortimer, Matthew Al‐Sarireh, Bilal Kanamarlapudi, Venkateswarlu Roy, Debdulal |
author_sort | Duckworth, Edward |
collection | PubMed |
description | OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. RESULTS: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet‐spots within blood plasma fractions containing molecules within a narrow range of molecular weights. |
format | Online Article Text |
id | pubmed-10501286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105012862023-09-15 Frontline clinical diagnosis—FTIR on pancreatic cancer Duckworth, Edward Mortimer, Matthew Al‐Sarireh, Bilal Kanamarlapudi, Venkateswarlu Roy, Debdulal Cancer Med RESEARCH ARTICLES OBJECTIVE: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. METHODS: A novel, affordable, non‐invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. RESULTS: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet‐spots within blood plasma fractions containing molecules within a narrow range of molecular weights. John Wiley and Sons Inc. 2023-07-19 /pmc/articles/PMC10501286/ /pubmed/37466344 http://dx.doi.org/10.1002/cam4.6346 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Duckworth, Edward Mortimer, Matthew Al‐Sarireh, Bilal Kanamarlapudi, Venkateswarlu Roy, Debdulal Frontline clinical diagnosis—FTIR on pancreatic cancer |
title | Frontline clinical diagnosis—FTIR on pancreatic cancer |
title_full | Frontline clinical diagnosis—FTIR on pancreatic cancer |
title_fullStr | Frontline clinical diagnosis—FTIR on pancreatic cancer |
title_full_unstemmed | Frontline clinical diagnosis—FTIR on pancreatic cancer |
title_short | Frontline clinical diagnosis—FTIR on pancreatic cancer |
title_sort | frontline clinical diagnosis—ftir on pancreatic cancer |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501286/ https://www.ncbi.nlm.nih.gov/pubmed/37466344 http://dx.doi.org/10.1002/cam4.6346 |
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