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Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives
Parkinson's disease-related constipation (PDC) is commonly associated with impaired dopamine transmission and gastrointestinal dysfunction. Current pharmacological treatments have limited efficacy and potential side effects. Acupuncture has shown promise as an alternative or adjunct therapy by...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501389/ https://www.ncbi.nlm.nih.gov/pubmed/37719758 http://dx.doi.org/10.3389/fneur.2023.1253874 |
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author | Zhang, Jiale Ge, Xiaolei Zhang, Kaiqi Qi, Yun Ren, Shuo Zhai, Xu |
author_facet | Zhang, Jiale Ge, Xiaolei Zhang, Kaiqi Qi, Yun Ren, Shuo Zhai, Xu |
author_sort | Zhang, Jiale |
collection | PubMed |
description | Parkinson's disease-related constipation (PDC) is commonly associated with impaired dopamine transmission and gastrointestinal dysfunction. Current pharmacological treatments have limited efficacy and potential side effects. Acupuncture has shown promise as an alternative or adjunct therapy by modulating the brain–gut axis, gastrointestinal hormones, and autonomic function. Preliminary randomized trials have shown that acupuncture significantly improves constipation symptoms, bowel movements, and comfort compared to sham or drug treatments and is well-tolerated. The mechanisms of action may involve regulating the gut microbiota and mucosal immunity to improve dysbiosis and gastrointestinal motility. However, more rigorous studies are required to optimize acupuncture protocols and determine long-term efficacy and safety. In summary, acupuncture shows promise as an adjunct therapy for PDC, but further research is needed to confirm its efficacy and safety. |
format | Online Article Text |
id | pubmed-10501389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105013892023-09-15 Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives Zhang, Jiale Ge, Xiaolei Zhang, Kaiqi Qi, Yun Ren, Shuo Zhai, Xu Front Neurol Neurology Parkinson's disease-related constipation (PDC) is commonly associated with impaired dopamine transmission and gastrointestinal dysfunction. Current pharmacological treatments have limited efficacy and potential side effects. Acupuncture has shown promise as an alternative or adjunct therapy by modulating the brain–gut axis, gastrointestinal hormones, and autonomic function. Preliminary randomized trials have shown that acupuncture significantly improves constipation symptoms, bowel movements, and comfort compared to sham or drug treatments and is well-tolerated. The mechanisms of action may involve regulating the gut microbiota and mucosal immunity to improve dysbiosis and gastrointestinal motility. However, more rigorous studies are required to optimize acupuncture protocols and determine long-term efficacy and safety. In summary, acupuncture shows promise as an adjunct therapy for PDC, but further research is needed to confirm its efficacy and safety. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10501389/ /pubmed/37719758 http://dx.doi.org/10.3389/fneur.2023.1253874 Text en Copyright © 2023 Zhang, Ge, Zhang, Qi, Ren and Zhai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Zhang, Jiale Ge, Xiaolei Zhang, Kaiqi Qi, Yun Ren, Shuo Zhai, Xu Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title | Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title_full | Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title_fullStr | Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title_full_unstemmed | Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title_short | Acupuncture for Parkinson's disease-related constipation: current evidence and perspectives |
title_sort | acupuncture for parkinson's disease-related constipation: current evidence and perspectives |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501389/ https://www.ncbi.nlm.nih.gov/pubmed/37719758 http://dx.doi.org/10.3389/fneur.2023.1253874 |
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