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Linking temporal coordination of hippocampal activity to memory function

Oscillations in neural activity are widespread throughout the brain and can be observed at the population level through the local field potential. These rhythmic patterns are associated with cycles of excitability and are thought to coordinate networks of neurons, in turn facilitating effective comm...

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Autores principales: Etter, Guillaume, Carmichael, James E., Williams, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501408/
https://www.ncbi.nlm.nih.gov/pubmed/37720546
http://dx.doi.org/10.3389/fncel.2023.1233849
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author Etter, Guillaume
Carmichael, James E.
Williams, Sylvain
author_facet Etter, Guillaume
Carmichael, James E.
Williams, Sylvain
author_sort Etter, Guillaume
collection PubMed
description Oscillations in neural activity are widespread throughout the brain and can be observed at the population level through the local field potential. These rhythmic patterns are associated with cycles of excitability and are thought to coordinate networks of neurons, in turn facilitating effective communication both within local circuits and across brain regions. In the hippocampus, theta rhythms (4–12 Hz) could contribute to several key physiological mechanisms including long-range synchrony, plasticity, and at the behavioral scale, support memory encoding and retrieval. While neurons in the hippocampus appear to be temporally coordinated by theta oscillations, they also tend to fire in sequences that are developmentally preconfigured. Although loss of theta rhythmicity impairs memory, these sequences of spatiotemporal representations persist in conditions of altered hippocampal oscillations. The focus of this review is to disentangle the relative contribution of hippocampal oscillations from single-neuron activity in learning and memory. We first review cellular, anatomical, and physiological mechanisms underlying the generation and maintenance of hippocampal rhythms and how they contribute to memory function. We propose candidate hypotheses for how septohippocampal oscillations could support memory function while not contributing directly to hippocampal sequences. In particular, we explore how theta rhythms could coordinate the integration of upstream signals in the hippocampus to form future decisions, the relevance of such integration to downstream regions, as well as setting the stage for behavioral timescale synaptic plasticity. Finally, we leverage stimulation-based treatment in Alzheimer's disease conditions as an opportunity to assess the sufficiency of hippocampal oscillations for memory function.
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spelling pubmed-105014082023-09-15 Linking temporal coordination of hippocampal activity to memory function Etter, Guillaume Carmichael, James E. Williams, Sylvain Front Cell Neurosci Cellular Neuroscience Oscillations in neural activity are widespread throughout the brain and can be observed at the population level through the local field potential. These rhythmic patterns are associated with cycles of excitability and are thought to coordinate networks of neurons, in turn facilitating effective communication both within local circuits and across brain regions. In the hippocampus, theta rhythms (4–12 Hz) could contribute to several key physiological mechanisms including long-range synchrony, plasticity, and at the behavioral scale, support memory encoding and retrieval. While neurons in the hippocampus appear to be temporally coordinated by theta oscillations, they also tend to fire in sequences that are developmentally preconfigured. Although loss of theta rhythmicity impairs memory, these sequences of spatiotemporal representations persist in conditions of altered hippocampal oscillations. The focus of this review is to disentangle the relative contribution of hippocampal oscillations from single-neuron activity in learning and memory. We first review cellular, anatomical, and physiological mechanisms underlying the generation and maintenance of hippocampal rhythms and how they contribute to memory function. We propose candidate hypotheses for how septohippocampal oscillations could support memory function while not contributing directly to hippocampal sequences. In particular, we explore how theta rhythms could coordinate the integration of upstream signals in the hippocampus to form future decisions, the relevance of such integration to downstream regions, as well as setting the stage for behavioral timescale synaptic plasticity. Finally, we leverage stimulation-based treatment in Alzheimer's disease conditions as an opportunity to assess the sufficiency of hippocampal oscillations for memory function. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10501408/ /pubmed/37720546 http://dx.doi.org/10.3389/fncel.2023.1233849 Text en Copyright © 2023 Etter, Carmichael and Williams. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Etter, Guillaume
Carmichael, James E.
Williams, Sylvain
Linking temporal coordination of hippocampal activity to memory function
title Linking temporal coordination of hippocampal activity to memory function
title_full Linking temporal coordination of hippocampal activity to memory function
title_fullStr Linking temporal coordination of hippocampal activity to memory function
title_full_unstemmed Linking temporal coordination of hippocampal activity to memory function
title_short Linking temporal coordination of hippocampal activity to memory function
title_sort linking temporal coordination of hippocampal activity to memory function
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501408/
https://www.ncbi.nlm.nih.gov/pubmed/37720546
http://dx.doi.org/10.3389/fncel.2023.1233849
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