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Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study

BACKGROUND: The cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microc...

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Autores principales: Magyar-Stang, Rita, István, Lilla, Pál, Hanga, Csányi, Borbála, Gaál, Anna, Mihály, Zsuzsanna, Czinege, Zsófia, Sótonyi, Péter, Tamás, Horváth, Koller, Akos, Bereczki, Dániel, Kovács, Illés, Debreczeni, Róbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501613/
https://www.ncbi.nlm.nih.gov/pubmed/37708176
http://dx.doi.org/10.1371/journal.pone.0291521
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author Magyar-Stang, Rita
István, Lilla
Pál, Hanga
Csányi, Borbála
Gaál, Anna
Mihály, Zsuzsanna
Czinege, Zsófia
Sótonyi, Péter
Tamás, Horváth
Koller, Akos
Bereczki, Dániel
Kovács, Illés
Debreczeni, Róbert
author_facet Magyar-Stang, Rita
István, Lilla
Pál, Hanga
Csányi, Borbála
Gaál, Anna
Mihály, Zsuzsanna
Czinege, Zsófia
Sótonyi, Péter
Tamás, Horváth
Koller, Akos
Bereczki, Dániel
Kovács, Illés
Debreczeni, Róbert
author_sort Magyar-Stang, Rita
collection PubMed
description BACKGROUND: The cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microcirculations. We aimed to characterize parameters indicating cerebrovascular reactivity (CVR) and retinal microvascular density in patients with ICA stenosis, and assess if there is correlation between them. METHODS: In this cross-sectional study the middle cerebral artery (MCA) blood flow velocity was measured by transcranial Doppler (TCD) and, simultaneously, continuous non-invasive arterial blood pressure measurement was performed on the radial artery by applanation tonometry. CVR was assessed based on the response to the common carotid artery compression (CCC) test. The transient hyperemic response ratio (THRR) and cerebral arterial resistance transient hyperemic response ratio (CAR-THRR) were calculated. Optical coherence tomography angiography (OCTA) was used to determine vessel density (VD) on the papilla whole image for all (VDP-WI(all)) and for small vessels (VDP-WI(small)). The same was done in the peripapillary region: all (VDPP(all)), and small (VDPP(small)) vessels. The VD of superficial (VDM(spf)) and deep (VDM(deep)) macula was also determined. Significance was accepted when p<0.05. RESULTS: Twenty-four ICA stenotic patients were evaluated. Both CVR and retinal VD were characterized. There was a significant, negative correlation between CAR-THRR (median = -0.40) and VDPP(small) vessels (median = 52%), as well as between VDPP(all) vessels (median = 58%), and similar correlation between CAR-THRR and VDP-WI(small) (median = 49.5%) and between VDP-WI(all) (median = 55%). CONCLUSION: The significant correlation between impaired cerebrovascular reactivity and retinal vessel density in patients with ICA stenosis suggests a common mechanism of action. We propose that the combined use of these diagnostic tools (TCD and OCTA) helps to better identify patients with increased ischemic or other cerebrovascular risks.
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spelling pubmed-105016132023-09-15 Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study Magyar-Stang, Rita István, Lilla Pál, Hanga Csányi, Borbála Gaál, Anna Mihály, Zsuzsanna Czinege, Zsófia Sótonyi, Péter Tamás, Horváth Koller, Akos Bereczki, Dániel Kovács, Illés Debreczeni, Róbert PLoS One Research Article BACKGROUND: The cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microcirculations. We aimed to characterize parameters indicating cerebrovascular reactivity (CVR) and retinal microvascular density in patients with ICA stenosis, and assess if there is correlation between them. METHODS: In this cross-sectional study the middle cerebral artery (MCA) blood flow velocity was measured by transcranial Doppler (TCD) and, simultaneously, continuous non-invasive arterial blood pressure measurement was performed on the radial artery by applanation tonometry. CVR was assessed based on the response to the common carotid artery compression (CCC) test. The transient hyperemic response ratio (THRR) and cerebral arterial resistance transient hyperemic response ratio (CAR-THRR) were calculated. Optical coherence tomography angiography (OCTA) was used to determine vessel density (VD) on the papilla whole image for all (VDP-WI(all)) and for small vessels (VDP-WI(small)). The same was done in the peripapillary region: all (VDPP(all)), and small (VDPP(small)) vessels. The VD of superficial (VDM(spf)) and deep (VDM(deep)) macula was also determined. Significance was accepted when p<0.05. RESULTS: Twenty-four ICA stenotic patients were evaluated. Both CVR and retinal VD were characterized. There was a significant, negative correlation between CAR-THRR (median = -0.40) and VDPP(small) vessels (median = 52%), as well as between VDPP(all) vessels (median = 58%), and similar correlation between CAR-THRR and VDP-WI(small) (median = 49.5%) and between VDP-WI(all) (median = 55%). CONCLUSION: The significant correlation between impaired cerebrovascular reactivity and retinal vessel density in patients with ICA stenosis suggests a common mechanism of action. We propose that the combined use of these diagnostic tools (TCD and OCTA) helps to better identify patients with increased ischemic or other cerebrovascular risks. Public Library of Science 2023-09-14 /pmc/articles/PMC10501613/ /pubmed/37708176 http://dx.doi.org/10.1371/journal.pone.0291521 Text en © 2023 Magyar-Stang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Magyar-Stang, Rita
István, Lilla
Pál, Hanga
Csányi, Borbála
Gaál, Anna
Mihály, Zsuzsanna
Czinege, Zsófia
Sótonyi, Péter
Tamás, Horváth
Koller, Akos
Bereczki, Dániel
Kovács, Illés
Debreczeni, Róbert
Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title_full Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title_fullStr Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title_full_unstemmed Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title_short Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
title_sort impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: cross-sectional, single center study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501613/
https://www.ncbi.nlm.nih.gov/pubmed/37708176
http://dx.doi.org/10.1371/journal.pone.0291521
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