Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss

The ELMOD3 gene is implicated in causing autosomal recessive/dominant non-syndromic hearing loss in humans. However, the etiology has yet to be completely elucidated. In this study, we generated a patient-derived iPSC line carrying ELMOD3 c.512A>G mutation. In addition, the patient-derived iPSC l...

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Detalles Bibliográficos
Autores principales: Liu, Xianlin, Wen, Jie, Liu, Xuezhong, Chen, Anhai, Li, Sijun, Liu, Jing, Sun, Jie, Gong, Wei, Kang, Xiaoming, Feng, Zhili, He, Chufeng, Mei, Lingyun, Ling, Jie, Feng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501637/
https://www.ncbi.nlm.nih.gov/pubmed/37708136
http://dx.doi.org/10.1371/journal.pone.0288640

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