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Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer

Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The...

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Autores principales: Zhang, Ke, Chen, Yuan, Zhu, Jie, Ge, Xinyu, Wu, Junqing, Xu, Peng, Yao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501729/
https://www.ncbi.nlm.nih.gov/pubmed/37720505
http://dx.doi.org/10.3389/fmed.2023.1213136
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author Zhang, Ke
Chen, Yuan
Zhu, Jie
Ge, Xinyu
Wu, Junqing
Xu, Peng
Yao, Jie
author_facet Zhang, Ke
Chen, Yuan
Zhu, Jie
Ge, Xinyu
Wu, Junqing
Xu, Peng
Yao, Jie
author_sort Zhang, Ke
collection PubMed
description Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment.
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spelling pubmed-105017292023-09-15 Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer Zhang, Ke Chen, Yuan Zhu, Jie Ge, Xinyu Wu, Junqing Xu, Peng Yao, Jie Front Med (Lausanne) Medicine Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. Frontiers Media S.A. 2023-08-31 /pmc/articles/PMC10501729/ /pubmed/37720505 http://dx.doi.org/10.3389/fmed.2023.1213136 Text en Copyright © 2023 Zhang, Chen, Zhu, Ge, Wu, Xu and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Ke
Chen, Yuan
Zhu, Jie
Ge, Xinyu
Wu, Junqing
Xu, Peng
Yao, Jie
Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title_full Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title_fullStr Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title_full_unstemmed Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title_short Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
title_sort advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501729/
https://www.ncbi.nlm.nih.gov/pubmed/37720505
http://dx.doi.org/10.3389/fmed.2023.1213136
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