A generic binding pocket for small molecule I(Ks) activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

The cardiac I(Ks) ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death. Pharmacological activators of I(Ks) are therefore of interest...

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Detalles Bibliográficos
Autores principales: Chan, Magnus, Sahakyan, Harutyun, Eldstrom, Jodene, Sastre, Daniel, Wang, Yundi, Dou, Ying, Pourrier, Marc, Vardanyan, Vitya, Fedida, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501768/
https://www.ncbi.nlm.nih.gov/pubmed/37707495
http://dx.doi.org/10.7554/eLife.87038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501768/
https://www.ncbi.nlm.nih.gov/pubmed/37707495
http://dx.doi.org/10.7554/eLife.87038

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