Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca(2+)(ER) perturbation in hepatocellular carcinoma

The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target for cancer treatment. However, results have often been disappointing due to crosstalk with other signals. Here, we report that IGF-1R signali...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Li, Keqin, Pan, Ting, Xie, Qiaobo, Cheng, Yuyao, Wu, Xinfeng, Xu, Rui, Liu, Xiaohui, Liu, Li, Gao, Jiangming, Yuan, Wenmin, Qu, Xianjun, Cui, Shuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501870/
https://www.ncbi.nlm.nih.gov/pubmed/37719369
http://dx.doi.org/10.1016/j.apsb.2023.05.031

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