Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis

Type 2 diabetes (T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1 (RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde (Rald) levels. However, the role of hepatic Rald deficiency in T2D progression remains unclear. In this study, we demonstrat...

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Detalles Bibliográficos
Autores principales: Yang, Hanyu, Su, Mengxiang, Liu, Ming, Sheng, Yun, Zhu, Liang, Yang, Lu, Mu, Ruijing, Zou, Jianjun, Liu, Xiaodong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501888/
https://www.ncbi.nlm.nih.gov/pubmed/37719384
http://dx.doi.org/10.1016/j.apsb.2023.06.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501888/
https://www.ncbi.nlm.nih.gov/pubmed/37719384
http://dx.doi.org/10.1016/j.apsb.2023.06.014

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