Cargando…

Anticancer action of naturally occurring emodin for the controlling of cervical cancer

One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades...

Descripción completa

Detalles Bibliográficos
Autores principales: Lande, Priyanka S., Adhao, Vaibhav S., Ambhore, Jaya P., Gaikwad, Kiran P., Chandak, Chanchal S., Joge, Leena P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501891/
https://www.ncbi.nlm.nih.gov/pubmed/37720346
http://dx.doi.org/10.37349/etat.2023.00161
_version_ 1785106203781627904
author Lande, Priyanka S.
Adhao, Vaibhav S.
Ambhore, Jaya P.
Gaikwad, Kiran P.
Chandak, Chanchal S.
Joge, Leena P.
author_facet Lande, Priyanka S.
Adhao, Vaibhav S.
Ambhore, Jaya P.
Gaikwad, Kiran P.
Chandak, Chanchal S.
Joge, Leena P.
author_sort Lande, Priyanka S.
collection PubMed
description One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades. The importance of natural sources as possible therapeutic candidates may be significant. Anthraquinones are one of the many chemical families of natural products, and they stand out for their wide range of structural variations, notable biological activity, and low toxicity. A natural substance called emodin, an anthraquinone derivative, is present in the roots and rhizomes of several plants. This substance has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties. It is also capable of preventing cancer spread and can reverse cancer cells’ multidrug resistance. Emodin, a broad-spectrum inhibitor of cancer cells, have anticancer properties in many different types of biological pathways. These molecular mechanisms in cancer cells include the suppression of cell growth and proliferation, deterioration of the cell cycle arrest, the start of apoptosis, antimetastasis, and antiangiogenic impact. Therefore, the aim of the present review summarised the antiproliferative and anticarcinogenic qualities of cervical cancer of emodin.
format Online
Article
Text
id pubmed-10501891
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Open Exploration Publishing
record_format MEDLINE/PubMed
spelling pubmed-105018912023-09-16 Anticancer action of naturally occurring emodin for the controlling of cervical cancer Lande, Priyanka S. Adhao, Vaibhav S. Ambhore, Jaya P. Gaikwad, Kiran P. Chandak, Chanchal S. Joge, Leena P. Explor Target Antitumor Ther Review One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades. The importance of natural sources as possible therapeutic candidates may be significant. Anthraquinones are one of the many chemical families of natural products, and they stand out for their wide range of structural variations, notable biological activity, and low toxicity. A natural substance called emodin, an anthraquinone derivative, is present in the roots and rhizomes of several plants. This substance has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties. It is also capable of preventing cancer spread and can reverse cancer cells’ multidrug resistance. Emodin, a broad-spectrum inhibitor of cancer cells, have anticancer properties in many different types of biological pathways. These molecular mechanisms in cancer cells include the suppression of cell growth and proliferation, deterioration of the cell cycle arrest, the start of apoptosis, antimetastasis, and antiangiogenic impact. Therefore, the aim of the present review summarised the antiproliferative and anticarcinogenic qualities of cervical cancer of emodin. Open Exploration Publishing 2023 2023-08-31 /pmc/articles/PMC10501891/ /pubmed/37720346 http://dx.doi.org/10.37349/etat.2023.00161 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Lande, Priyanka S.
Adhao, Vaibhav S.
Ambhore, Jaya P.
Gaikwad, Kiran P.
Chandak, Chanchal S.
Joge, Leena P.
Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title_full Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title_fullStr Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title_full_unstemmed Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title_short Anticancer action of naturally occurring emodin for the controlling of cervical cancer
title_sort anticancer action of naturally occurring emodin for the controlling of cervical cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501891/
https://www.ncbi.nlm.nih.gov/pubmed/37720346
http://dx.doi.org/10.37349/etat.2023.00161
work_keys_str_mv AT landepriyankas anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer
AT adhaovaibhavs anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer
AT ambhorejayap anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer
AT gaikwadkiranp anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer
AT chandakchanchals anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer
AT jogeleenap anticanceractionofnaturallyoccurringemodinforthecontrollingofcervicalcancer