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Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas
Tri methylguanosine synthase 1 (TGS1) is the enzyme that hyper methylates the hallmark 7-methyl-guanosine cap (m7G-cap) appended to the transcription start site of RNAs. The m7G-cap and the eIF4E-cap binding protein guide canonical cap-dependent translation of mRNAs, whereas hyper methylated cap, m2...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group US
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501901/ https://www.ncbi.nlm.nih.gov/pubmed/37386121 http://dx.doi.org/10.1038/s41417-023-00636-9 |