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Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells

Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with a poor prognosis and an elevated tendency of metastases, as a possible soluble mediator of inter-cellular communi...

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Detalles Bibliográficos
Autores principales:	Mancarella, Caterina, Giusti, Veronica, Caldoni, Giulia, Laginestra, Maria Antonella, Parra, Alessandro, Toracchio, Lisa, Giordano, Giorgia, Roncuzzi, Laura, Piazzi, Manuela, Blalock, William, Columbaro, Marta, De Feo, Alessandra, Scotlandi, Katia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501906/ https://www.ncbi.nlm.nih.gov/pubmed/37353558 http://dx.doi.org/10.1038/s41417-023-00637-8

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