Cargando…

Multi-cancer analysis reveals universal association of oncogenic LBH expression with DNA hypomethylation and WNT-Integrin signaling pathways

Limb-Bud and Heart (LBH) is a developmental transcription co-factor deregulated in cancer, with reported oncogenic and tumor suppressive effects. However, LBH expression in most cancer types remains unknown, impeding understanding of its mechanistic function Here, we performed systematic bioinformat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Young, In-Chi, Brabletz, Thomas, Lindley, Linsey E., Abreu, Maria, Nagathihalli, Nagaraj, Zaika, Alexander, Briegel, Karoline J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501907/ https://www.ncbi.nlm.nih.gov/pubmed/37268816 http://dx.doi.org/10.1038/s41417-023-00633-y

Ejemplares similares

The T Box Transcription Factor TBX2 Promotes Epithelial-Mesenchymal Transition and Invasion of Normal and Malignant Breast Epithelial Cells
por: Wang, Bin, et al.
Publicado: (2012)

Overexpression of LBH is associated with poor prognosis in human hepatocellular carcinoma
por: Chen, Jiewei, et al.
Publicado: (2018)

Hypoxia induced LBH overexpression accelerates malignant progression in glioma
por: Zhang, Ke-Nan, et al.
Publicado: (2019)

LncRNA MIR31HG Drives Oncogenicity by Inhibiting the Limb-Bud and Heart Development Gene (LBH) during Oral Carcinoma
por: Chang, Kuo-Wei, et al.
Publicado: (2021)

Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation
por: Li, Wen-Hua, et al.
Publicado: (2015)

A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma
por: Ibrahim, Nageatte, et al.
Publicado: (2016)

Limb‐bud and heart development (LBH) contributes to glioma progression in vitro and in vivo
por: Liu, Luotong, et al.
Publicado: (2021)

WNT3 hypomethylation counteracts low activity of the Wnt signaling pathway in the placenta of preeclampsia
por: Zhang, Linlin, et al.
Publicado: (2021)

Integrins, Oncogenes, and Anchorage Independence
por: Schwartz, Martin Alexander
Publicado: (1997)

HDAC Inhibition by LBH589 Affects Phenotype and Function of Human Myeloid Dendritic Cells
por: Song, W, et al.
Publicado: (2010)

Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway
por: Yu, Ruoxi, et al.
Publicado: (2019)

Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways
por: Nagaraj, Nagathihalli S, et al.
Publicado: (2004)

Targeting PI3K Pathway in Pancreatic Ductal Adenocarcinoma: Rationale and Progress
por: Mehra, Siddharth, et al.
Publicado: (2021)

Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer
por: Mehra, Siddharth, et al.
Publicado: (2022)

Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome
por: Grimm, Juliane, et al.
Publicado: (2022)

Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer
por: Garrett, Leslie A., et al.
Publicado: (2016)

HDAC Inhibitor LBH589 Suppresses the Proliferation but Enhances the Antileukemic Effect of Human γδT Cells
por: He, Ying, et al.
Publicado: (2020)

New mechanistic insights into modifiable risk factors that promote pancreatic cancer
por: Srinivasan, Supriya, et al.
Publicado: (2019)

Integrin α6β4 Upregulates Amphiregulin and Epiregulin through Base Excision Repair-Mediated DNA Demethylation and Promotes Genome-wide DNA Hypomethylation
por: Carpenter, Brittany L., et al.
Publicado: (2017)

Combination Therapy with the Histone Deacetylase Inhibitor LBH589 and Radiation Is an Effective Regimen for Prostate Cancer Cells
por: Xiao, Weiwei, et al.
Publicado: (2013)

The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines
por: Klein, Jan M., et al.
Publicado: (2013)

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease
por: Chopra, Vanita, et al.
Publicado: (2016)

Exosomal LBH inhibits epithelial-mesenchymal transition and angiogenesis in nasopharyngeal carcinoma via downregulating VEGFA signaling
por: Wu, Anbiao, et al.
Publicado: (2022)

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines
por: LaBonte, Melissa J, et al.
Publicado: (2009)

Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes
por: Chen, Cheng, et al.
Publicado: (2022)

Emerging targets in pancreatic cancer: epithelial–mesenchymal transition and cancer stem cells
por: Castellanos, Jason A, et al.
Publicado: (2013)

Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer
por: Wolff, Erika M., et al.
Publicado: (2010)

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
por: Cain, Jason E., et al.
Publicado: (2013)

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway
por: Song, Xuan, et al.
Publicado: (2013)

Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway
por: Sheng, Bo, et al.
Publicado: (2023)

Dynamic EMT: a multi‐tool for tumor progression
por: Brabletz, Simone, et al.
Publicado: (2021)

Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis
por: Palrasu, Manikandan, et al.
Publicado: (2022)

Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer
por: Höbaus, Julia, et al.
Publicado: (2013)

Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation
por: Søes, Signe, et al.
Publicado: (2014)

The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells
por: Lisiero, Dominique N, et al.
Publicado: (2014)

Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells
por: Yan-Fang, Tao, et al.
Publicado: (2015)

Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells
por: Lin, Zhaohu, et al.
Publicado: (2017)

Limb-Bud and Heart (LBH) Upregulation in Cardiomyocytes under Hypoxia Promotes the Activation of Cardiac Fibroblasts via Exosome Secretion
por: Xu, Yuling, et al.
Publicado: (2022)

Consistent DNA Hypomethylations in Prostate Cancer
por: Araúzo-Bravo, Marcos J., et al.
Publicado: (2022)

Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor
por: Hamberg, Paul, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7trq39h2bpn89pmba3j97e725f